Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1
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Summary
PP2A:B56δ is shown to be a key upstream regulator of Cdk1 activity upon exit from mitosis, and stable knockdown and germ-line mouse KO of B 56δ leads to compensatory transcriptional up-regulation of Wee1 kinase to oppose the Cdc25C activity and permit cell survival.
- Type
- article
- Published
- 2007-12-11
- Cited by
- 95
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W18056802
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:731104
Keywords
Geology
References
- Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.
- Temporal and spatial control of cyclin B1 destruction in metaphase
- Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
- Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.
- In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
- Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity.
- Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
- Mad2 phosphorylation regulates its association with Mad1 and the APC/C
- Protein Phosphatase 2A Regulatory Subunit B56α Associates with c-Myc and Negatively Regulates c-Myc Accumulation
- PP2A: the expected tumor suppressor.
- Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
- The tumor suppressor PP2A Abeta regulates the RalA GTPase.
- Cyclin is degraded by the ubiquitin pathway
- Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.
- c‐Fos/activator protein‐1 transactivates wee1 kinase at G1/S to inhibit premature mitosis in antigen‐specific Th1 cells
- Role for Non-Proteolytic Control of M-phase Promoting Factor Activity at M-phase Exit
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin
- Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.
- Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.
- The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
Cited by
- Entrainment of the Mammalian Cell Cycle by the Circadian Clock: Modeling Two Coupled Cellular Rhythms
- Regulation of DNA Double Strand Break Response
- Regulation of the tumour suppressor PP2A by oncogenic tyrosine kinases
- Regulatory roles of calprotectin in head and neck squamous cell carcinogenesis.
- B56δ subunit of protein phosphatase 2A decreases phosphorylation of endothelial nitric oxide synthase at serine 116: Mechanism underlying aphidicolin-stimulated NO production.
- Implication de la voie ERK3/4-MK5 dans la phase G2/M du cycle cellulaire
- TRPV3 Channel Negatively Regulates Cell Cycle Progression and Safeguards the Pluripotency of Embryonic Stem Cells
- Influence of proline‐rich inositol polyphosphate 5‐phosphatase, on early development of fertilized mouse eggs, via inhibition of phosphorylation of Akt
- FGF inhibits the activity of the cyclin B1/CDK1 kinase to induce a transient G2 arrest in RCS chondrocytes
- S100A8/A9 (Calprotectin) Negatively Regulates G2/M Cell Cycle Progression and Growth of Squamous Cell Carcinoma
- PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos
- HEAT Repeat 1 Motif Is Required for B56γ-containing Protein Phosphatase 2A (B56γ-PP2A) Holoenzyme Assembly and Tumor-suppressive Function*
- A B56γ mutation in lung cancer disrupts the p53-dependent tumor suppressor function of protein phosphatase 2A
- Protein phosphatase 1 dephosphorylates Orc2.
- Regulation and Function of Protein Kinases and Phosphatases
- PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1.
- Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis
- Cyclin E Overexpression Impairs Mitotic Progression Through Premature Activation of Cdc25C and Deregulation of Cyclin B/CDK1 and PLK1 Activities
- Protein kinase D isozymes activation and localization during mitosis
- Clk2 and B56β mediate insulin regulated assembly of the PP2A phosphatase holoenzyme complex on Akt
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