Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
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Summary
Human Kruppel-like factor 2 (KLF2) is a Cys2/His2 zinc-finger-containing transcriptional factor, which is involved in multiple cellular pathways and inhibits WEE1 transcription, and enhanced KLF2 expression sensitizes cells to DNA damage-induced apoptosis.
- Type
- article
- Published
- 2005-06-02
- Cited by
- 85
- References
- 34
- OpenAlex
- https://openalex.org/W1981721183
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25273554
Keywords
Wee1, KLF2, Biology, Zinc finger, Cancer research
References
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Cited by
- Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer
- Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1
- Fatty Acid-binding Protein 5 and PPARβ/δ Are Critical Mediators of Epidermal Growth Factor Receptor-induced Carcinoma Cell Growth*
- MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
- Differentially Regulated pathways of Potential Importance for Treatment Response and Cardiac Toxicity after Administration of Doxorubicine to BC Patients
- The biology of Krüppel-like factors
- Microarray analysis of differentially regulated genes in human leukemia cells after expression of the inositol 5-phosphatase SHIP
- Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2
- CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
- Effect of proton and gamma irradiation on human lung carcinoma cells: Gene expression, cell cycle, cell death, epithelial-mesenchymal transition and cancer-stem cell trait as biological end points.
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- The Nedd4-like family of E3 ubiquitin ligases and cancer
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- Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis
- Long Noncoding RNA ANRIL Promotes Non–Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression
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- Up‐regulation of the T cell quiescence factor KLF2 in a leukaemic T‐cell line after expression of the inositol 5′‐phosphatase SHIP‐1
- A module of negative feedback regulators defines growth factor signaling
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