Mathematical Model for Spatial Segregation of the Rho-Family GTPases Based on Inhibitory Crosstalk
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Summary
It is shown that cooperativity is an essential ingredient in the interactions of the proteins, and the fast diffusion of the inactive forms is essential for stabilizing the transition fronts in the PDE formulation of the model, leading to robust spatial polarization, rather than traveling waves.
- Type
- article
- Published
- 2007-04-25
- Cited by
- 157
- References
- 81
- OpenAlex
- https://openalex.org/W17457653
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:411851
Keywords
Humanities, Physics, Art
References
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- Cellular-level mechanisms of polarity and their role in plant growth
- Directional sensing and actin dynamics in dictyostelium discoideum amoebae.
- Theoretical models of neural circuit development.
- On the biomechanics of stem cell niche formation in the gut – modelling growing organoids
- Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
- Mathematical Modelling of Polarizing GTPases in Developing Axons
- How to get moving: lessons in eukaryotic motility from a prototypic model of cell polarization
- A hybrid computational model to predict chemotactic guidance of growth cones
- Juicy stories on female reproductive tissue development: coordinating the hormone flows.
- From simple to detailed models for cell polarization
- Bidirectional molecular transport shapes cell polarization in a two-dimensional model of eukaryotic chemotaxis.
- Modelling Cell Polarization Driven by Synthetic Spatially Graded Rac Activation
- A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules
- Parameter-space topology of models for cell polarity
- Computational models of sprouting angiogenesis and cell migration: towards multiscale mechanochemical models of angiogenesis
- Spatially Distributed Cell Signalling
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