Down‐Regulation of Thioredoxin1 Is Involved in Death of Calu‐6 Lung Cancer Cells Treated With Suberoyl Bishydroxamic Acid
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Summary
The down‐regulation of Trx1 by SBHA was closely involved in cell death in Calu‐6 cells, and the overexpression of TrX1 attenuated apoptosis and ROS level in these cells.
- Type
- article
- Published
- 2016-05-01
- Cited by
- 5
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1943552159
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21265089
Keywords
Apoptosis, Reactive oxygen species, Programmed cell death, Cancer cell, Histone deacetylase inhibitor
References
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- The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants
- New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
- Suberoyl bishydroxamic acid inhibits the growth of A549 lung cancer cells via caspase-dependent apoptosis
- Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung
Cited by
- Suberoylanilide hydroxamic acid induces thioredoxin1‐mediated apoptosis in lung cancer cells via up‐regulation of miR‐129‐5p
- Upregulated thioredoxin and its reductase prevent H2O2-induced growth inhibition and death in human pulmonary artery smooth muscle cells.
- Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress.
- Tempol differently affects cellular redox changes and antioxidant enzymes in various lung-related cells
- Regulatory effect of Panax notoginseng saponins on the oxidative stress and histone acetylation induced by porcine circovirus type 2
- Tempol Differently Affects Cellular Redox Status and Antioxidant Enzymes in Various Lung-related Cells
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