CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes
Explore this paper's citation graph
Summary
The ISL8Spot assay is capable of detecting and quantifying β-cell–reactive CD8+ T-cells directly ex vivo, without any preliminary expansion, using either fresh or frozen samples, and may open new avenues toward type 1 diabetes prediction and prevention.
- Type
- article
- Published
- 2007-03-01
- Cited by
- 148
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W17327428
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24825886
Keywords
Computer science
References
- Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant
- Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.
- Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.
- Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins.
- Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
- HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes1
- Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein-Reactive CD4+ T Cells in Human Subjects1
- Identification of a CD8 T Cell That Can Independently Mediate Autoimmune Diabetes Development in the Complete Absence of CD4 T Cell Helper Functions1
- Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes1
- Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
- Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes.
- Development of type 1 diabetes despite severe hereditary B-cell deficiency.
- Latent autoimmune diabetes in adults (LADA) should be less latent
- Therapy of autoimmune diseases: clinical trials and new biologics.
- The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice
- SYFPEITHI: database for MHC ligands and peptide motifs
- Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.
- Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.
- A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin.
- Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays.
Cited by
- Immunotargeting of insulin reactive CD8 T cells to prevent diabetes.
- Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes
- Immunoproteasomes: Structure, Function, and Antigen Presentation
- Short‐term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice
- CD8+ T cells in type 1 diabetes.
- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.
- Compensatory Mechanisms Allow Undersized Anchor-deficient Class I MHC Ligands to Mediate Pathogenic Autoreactive T Cell Responses
- Cell-mediated immunity in recent-onset type 1 diabetic children
- Does dysregulation of immune responses in the tonsils play an important role in the pathology of psoriasis
- Generation of β cell‐specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen‐transgenic mice
- T‐cell autoantigens in the non‐obese diabetic mouse model of autoimmune diabetes
- Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice1
- Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes.
- Immunology of Addison's disease and premature ovarian failure.
- Intravenous immunoglobulin modulates the expansion and cytotoxicity of CD8+ T cells
- Improving the timeframe between blood collection and interferon gamma release assay using T-Cell Xtend®.
- Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies
- Beta cell apoptosis in diabetes
- Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays
- Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Related papers
No related papers recorded.