Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
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Summary
It is reported that the initial steps in postsynaptic differentiation and formation of an end-plate band require MuSK and rapsyn, but are not dependent on agrin or the presence of motor axons, while the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve- derived signal that disperses ectopic post synaptic apparatus.
- Type
- article
- Published
- 2001-04-26
- Cited by
- 551
- References
- 44
- OpenAlex
- https://openalex.org/W1512382989
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4372222
Keywords
Agrin, Postsynaptic potential, Neuromuscular junction, Neuroscience, Synapse
References
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- Spontaneous release of transmitter from growth cones of embryonic neurones
- The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
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- The agrin hypothesis.
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- Distribution and substrate properties of agrin, a heparan sulfate proteoglycan of developing axonal pathways
- Basal lamina components are concentrated in premuscle masses and at early acetylcholine receptor clusters in chick embryo hindlimb muscles.
Cited by
- Development of neuromuscular junctions in the mouse esophagus: focus on establishment and reduction of enteric co-innervation
- Neuromuscular synaptogenesis: clustering of acetylcholine receptors revisited
- Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.
- β1 Integrins in Muscle, But Not in Motor Neurons, Are Required for Skeletal Muscle Innervation
- Formation and Plasticity of Neuromuscular Synaptic Connections
- Agrin is highly expressed by chondrocytes and is required for normal growth
- Synaptic transmission is impaired at neuronal autonomic synapses in agrin‐null mice
- Heparan sulfate proteoglycans in the basement membranes of the human placenta and decidua.
- Synapse formation and remodeling
- Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions
- Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation
- Moving forward with the neuromuscular junction
- Participació dels receptors muscarínics presinàptics (mAChRs) en l'eliminació de les connexions sinàptiques redundants durant el desenvolupament neuromuscular
- Elucidating the molecular mechanisms that underlie the target control of motoneuron death.
- LGMD-1C: Role of Caveolin-3 in Neuromuscular Junction Structure and Function
- Vers la compréhension des mécanismes moléculaires et physiopathologiques à l'origine de l'hyperactivité neuromusculaire dans le syndrome de Schwartz-Jampel
- Myasthénie et auto-anticorps : physiopathologie des différentes entités
- Ear manipulations help model neuroplasticity limitations
- Development and characterisation of a novel myotube-motoneuron 3D co-culture system
- The Effect of Acetylcholine on the Reduction of the Required Voltage for Muscle Contraction
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