Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

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Summary

It is reported that the initial steps in postsynaptic differentiation and formation of an end-plate band require MuSK and rapsyn, but are not dependent on agrin or the presence of motor axons, while the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve- derived signal that disperses ectopic post synaptic apparatus.

Type
article
Published
2001-04-26
Cited by
551
References
44

Keywords

Agrin, Postsynaptic potential, Neuromuscular junction, Neuroscience, Synapse

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