Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target
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Summary
Tumor necrosis factor receptor associated factor 4 mRNA expression is up-regulated in various breast tumors and tumor cell lines and Traf4 appears to enhance β-catenin related transcription as well as provide some protection of β- catenin protein levels from p53-mediated degradation although a direct interaction was not observed in mammalian cells.
- Type
- article
- Published
- 2006-08-30
- Cited by
- 31
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2044134609
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35605764
Keywords
Immunoprecipitation, Biology, Cell biology, Molecular biology, Cell culture
References
- All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.
- Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly
- Involvement of TRAF4 in Oxidative Activation of c-Jun N-terminal Kinase*
- Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
- The p62 Scaffold Regulates Nerve Growth Factor-induced NF-κB Activation by Influencing TRAF6 Polyubiquitination*
- Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
- Identification of GRIM-19, a Novel Cell Death-regulatory Gene Induced by the Interferon-β and Retinoic Acid Combination, Using a Genetic Approach*
- GRIM‐19, a death‐regulatory gene product, suppresses Stat3 activity via functional interaction
- PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins*
- Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
- Presence of a New Conserved Domain in CART1, a Novel Member of the Tumor Necrosis Factor Receptor-associated Protein Family, Which Is Expressed in Breast Carcinoma (*)
- p53 downstream target genes and tumor suppression: a classical view in evolution
- Human PRMT5 Expression Is Enhanced during in vitro Tubule Formation and after in vivo Ischemic Injury in Renal Epithelial Cells
- Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
- Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
- Altered cytoskeleton organization in platelets from patients with MYH9‐related disease
- Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
- Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel–Lindau protein
- Stabilization of beta-catenin by genetic defects in melanoma cell lines.
- MEKK4 Is an Effector of the Embryonic TRAF4 for JNK Activation*
Cited by
- TRAF4 promotes tumorigenesis of breast cancer through activation of Akt.
- TRAF4 promotes the growth and invasion of colon cancer through the Wnt/β-catenin pathway.
- MicroRNA-370 inhibits the progression of non-small cell lung cancer by downregulating oncogene TRAF4.
- Expression, correlation, and prognostic value of TRAF2 and TRAF4 expression in malignant plural effusion cells in human breast cancer
- Kinesin-5: cross-bridging mechanism to targeted clinical therapy
- The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1 phase arrest and transition into granulocytic differentiation
- Platelet-activating factor induces proliferation in differentiated keratinocytes
- TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus
- TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN
- Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression
- Identification of Cellular Proteins Interacting with Equine Infectious Anemia Virus S2 Protein
- The phosphoinositide-binding protein TRAF4 modulates tight junction stability and migration of cancer cells
- Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.
- Role for Traf4 in Polarizing Adherens Junctions as a Prerequisite for Efficient Cell Shape Changes
- TRAF molecules in cell signaling and in human diseases
- [TRAF4, a multifaceted protein involved in carcinoma progression].
- Advancement of Wnt signal pathway and the target of breast cancer
- Identification of Cancer Stem Cell Molecular Markers and Effects of hsa-miR-21-3p on Stemness in Esophageal Squamous Cell Carcinoma
- Recognition of TRAIP with TRAFs: current understanding and associated diseases.
- TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin
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