Structure-based prediction of insertion-site preferences of transposons into chromosomes
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Summary
An automated method, ProTIS©, is developed that can generate profiles of predicted integration events for Sleeping Beauty transposons into whole plasmids and chromosomal DNA and may be useful for other mobile elements once a sufficiently high density of sites in a single region are obtained.
- Type
- article
- Published
- 2006-05-22
- Cited by
- 81
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W16717285
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1639235
Keywords
Computer science
References
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Cited by
- The use of DNA transposons for cancer gene discovery in mice.
- Liver-directed gene therapy using the sleeping beauty transposon system.
- Transposon-based technology enhances the generation of stable and high-producing CHO clones for industrial production of recombinant proteins and antibodies
- A hybrid lentivirus-transposon vector for safer gene therapy
- Sleeping Beauty Transposition
- Computational prediction of Ds transposon insertion sites in plants using DNA structural features
- Characterizing the Role of 1p36 Deletion in Breast Cancer and Identifying Candidate Tumor Suppressors
- Development of Augmented Leukemia/Lymphoma-Specific T-Cell Immunotherapy for Deployment with Haploidentical Hematopoietic Progenitor-Cell Transplant
- Nonviral Gene Delivery with the Sleeping Beauty Transposon System
- Chromatin Landscapes of Retroviral and Transposon Integration Profiles
- Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy
- PiggyBac transposon-mediated gene transfer in human cells.
- Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish
- Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.
- Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.
- Nonviral gene therapy for age-related macular degeneration
- Sleeping beauty--a mouse model for all cancers?
- Structural Properties of Prokaryotic Promoter Regions Correlate with Functional Features
- Evaluating Risks of Insertional Mutagenesis by DNA Transposons in Gene Therapy
- DNA Structural Properties in the Classification of Genomic Transcription Regulation Elements
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