Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1.
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Summary
Exposure of LNCaP cells to IL-1beta at picomole ranges resulted in a dose-dependent and progressive differentiation to neuroendocrine-like cells evidenced by dendrite formation and the development of specific neuro endocrine cell markers.
- Type
- article
- Published
- 1999-11-01
- Cited by
- 38
- References
- 0
- OpenAlex
- https://openalex.org/W2013806657
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44510952
Keywords
LNCaP, Chromogranin A, Biology, Autocrine signalling, Prostate cancer
References
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Cited by
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- Multipathways for transdifferentiation of human prostate cancer cells into neuroendocrine-like phenotype.
- Autocrine Production of Interleukin 1β Confers Constitutive Nuclear Factor κB Activity and Chemoresistance in Pancreatic Carcinoma Cell Lines
- The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
- Progression of prostate cancer to neuroendocrine cell tumor
- Proliferation of prostate cancer cells and activity of neutral endopeptidase is regulated by bombesin and IL‐1β with IL‐1β acting as a modulator of cellular differentiation
- In silico dissection of cell-type-associated patterns of gene expression in prostate cancer.
- Augmented expression of chromogranin A and serotonin in peri-malignant benign prostate epithelium as compared to adenocarcinoma.
- Neuroendocrine differentiation of the LNCaP prostate cancer cell line maintains the expression and function of VIP and PACAP receptors.
- Androgen ablation promotes neuroendocrine cell differentiation in dog and human prostate
- Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma
- Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro.
- Ki67 staining index and neuroendocrine differentiation aggravate adverse prognostic parameters in prostate cancer and are characterized by negligible inter-observer variability
- Interferon‐γ induces neuroendocrine‐like differentiation of human prostate basal‐epithelial cells
- Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6‐IL6 Loop
- Interleukin-1--a major pleiotropic cytokine in tumor-host interactions.
- A case of uterine cervical adenocarcinoma associated with small cell carcinoma
- Neuroendocrine-like prostate cancer cells: neuroendocrine transdifferentiation of prostate adenocarcinoma cells.
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