EGFR Mutation Status in Japanese Lung Cancer Patients: Genotyping Analysis Using LightCycler
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Summary
Genotyped EGFR mutation status in Japanese lung cancer patients found that the EGFR L858R mutation status might correlate with gender, pathologic subtypes, and gefitinib sensitivity of lung cancers, and EGFR gene status, including the type of EGFR somatic mutation, was correlated with sensitivity to gefitsinib therapy.
- Type
- article
- Published
- 2005-04-15
- Cited by
- 127
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W15837743
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15244299
Keywords
Surface (topology), Coupling (piping), Flow (mathematics), Temporal scales, Computer science
References
- The LightCycler: a microvolume multisample fluorimeter with rapid temperature control.
- Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung.
- The polymerase chain reaction. A new method of using molecular genetics for medical diagnosis.
- Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study.
- The conformational plasticity of protein kinases.
- Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
- Detection of a single base substitution in a single cell using the LightCycler.
- Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer
- Anticancer drugs: To the rescue?
- A rapid and sensitive approach to mutation detection using real-time polymerase chain reaction and melting curve analyses, using BRCA1 as an example.
- Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer.
- Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.
- EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
- Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
- Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib (‘Iressa’, ZD1839) in non-small-cell lung cancer
- [The outline of the general rule for clinical and pathological record of lung cancer].
- [Cancer of the lung].
- Continuous fluorescence monitoring of rapid cycle DNA amplification.
Cited by
- Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy.
- Detection of Epidermal Growth Factor Receptor Mutations in Serum as a Predictor of the Response to Gefitinib in Patients with Non–Small-Cell Lung Cancer
- Evaluation of Kras Gene Mutation and Copy Number Gain in Non-small Cell Lung Cancer
- Hypermethylation of the large tumor suppressor genes in Japanese lung cancer.
- Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR GreenI-based assay: determining FAT10 mRNA levels in hepatocellular carcinoma.
- Elucidating the cause of FAT10 over-expression in liver and colon carcinomas
- 细针吸取细胞学标本检测非小细胞肺癌EGFR、KRAS突变的探讨
- 非小细胞肺癌EGFR突变的检测方法
- Prediction of epidermal growth factor receptor mutations in the plasma/pleural effusion to efficacy of gefitinib treatment in advanced non-small cell lung cancer
- Treatment of non-small-cell lung cancer and pharmacogenomics: where we are and where we are going
- Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.
- EGFR exon 20 insertion mutation in Japanese lung cancer.
- Leptomeningeal metastases from small cell lung cancer responsive to temozolomide therapy.
- Roles of pathologists in molecular targeted cancer therapy
- Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors
- MEK1 gene mutation in Japanese lung adenocarcinoma patients.
- Detection of epidermal growth factor receptor variations by partially denaturing HPLC.
- Rapid Detection of Epidermal Growth Factor Receptor Mutations in Non‐Small Cell Lung Cancer Using Real‐Time Polymerase Chain Reaction with TaqMan‐MGB Probes
- Clinical experience with gefitinib: an update.
- Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients.
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