Anticancer drugs: To the rescue?

Summary

Tumour biopsies from eight out of nine patients with gefitinib-responsive lung cancer carried these mutations, compared with none from seven nonresponders, and five out of five samples selected that had EGFR mutations were from treatment responders.

Keywords

Computational biology, Computer science, Medicine, Intensive care medicine, Biology

References

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionAdam Siddiqui-Jain, Cory L. Grand, David J. Bearss — 2002
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.C. Grand, T. J. Powell, R. Nagle — 2004

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