Hypermethylation of the large tumor suppressor genes in Japanese lung cancer.
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Summary
The EGFR methylation status of the LATS genes has limited value in Japanese lung cancers as the methylation statuses did not correlate with survival of lung cancer patients.
- Type
- article
- Published
- 2010-03-01
- Cited by
- 21
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W22966299
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36685251
Keywords
Musical, Art, Humanities, Hasta, Visual arts
References
- EGFR Mutation Status in Japanese Lung Cancer Patients: Genotyping Analysis Using LightCycler
- Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
- Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
- Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice
- Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.
- Lats2, a putative tumor suppressor, inhibits G1/S transition
- LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
- Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay.
- Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
- Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).
- A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.
- Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia
- A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
- EGFR and erbB2 mutation status in Japanese lung cancer patients
- Lats2 Is an Essential Mitotic Regulator Required for the Coordination of Cell Division*
- Inhibition of Cell Growth by Conditional Expression of kpm, a Human Homologue of Drosophila warts/lats Tumor Suppressor*
- The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
- Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
- Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers
- Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
Cited by
- The Hippo pathway in chemotherapeutic drug resistance
- Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer
- 17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway
- Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas
- Long Noncoding RNA PVT1 Promotes Non–Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression
- Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation
- Contribution of LATS1 and LATS2 promoter methylation in OSCC development
- Molecular Alterations and Expression Dynamics of LATS1 and LATS2 Genes in Non-Small-Cell Lung Carcinoma
- Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome.
- The NDR/LATS protein kinases in immunology and cancer biology.
- The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
- LATS1 (Large Tumor Suppressor 1)
- Hypermethylated LATS2 gene with decreased expression in female breast cancer: A case control study from North India.
- Dysregulation of the Hippo pathway signaling in aging and cancer
- LINC00511 promotes the progression of non-small cell lung cancer through downregulating LATS2 and KLF2 by binding to EZH2 and LSD1.
- Promoter Hypermethylation of LATS2 Gene in Oral Squamous Cell Carcinoma (OSCC) among North Indian Population
- m6A methyltransferase METTL3-induced lncRNA SNHG17 promotes lung adenocarcinoma gefitinib resistance by epigenetically repressing LATS2 expression
- LATS in cancer repression: Extracting its role in hippo pathway and beyond
- Long Noncoding RNA PVT 1 Promotes Non – Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS 2 Expression
- Targeting the Hippo Pathway to Improve Response to Chemotherapy
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