p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis
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Summary
The p53 mutations, at least in these tumours, have not contributed to melanomagenesis and may have originated after establishment of the primary tumour, indicating that a role for sun exposure was indicated.
- Type
- article
- Published
- 1999-02-01
- Cited by
- 88
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W10070891
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10353800
Keywords
Geography
References
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- p53 mutations in basal cell carcinomas.
- p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin.
- Absence of p53 gene mutations in cutaneous melanoma.
- Sunburn and p53 in the onset of skin cancer
- TP53 allele loss, mutations and expression in malignant melanoma.
- Gradual selection of a cellular clone presenting a mutation at codon 179 of the p53 gene during establishment of the immortalized human breast epithelial cell line HMT-3522.
- Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma
- Frequent mutations of the p53 gene in cutaneous melanoma of the nodular type
- p53 gene mutation and expression in naevi and melanomas
- Mutation and expression of the p53 gene in malignant melanoma cell lines
- Mutation and expression of the p53 gene in human malignant melanoma
- Mutational analysis of the human p53 gene in malignant melanoma.
- Overexpression and mutations of p53 in metastatic malignant melanomas
Cited by
- Ultraviolet B-induced melanoma in Monodelphis domestica occurs in the absence of alterations in the structure or expression of the p53 gene
- Overcoming resistance to apoptosis in cancer therapy.
- Development of malignant melanoma is dependent on a switch in Embryonic Transcription Factors orchestrated by the BRAF-MAPK pathway
- Prognostic factors of primary cutaneous melanoma
- Animal models of melanoma: recent advances and future prospects.
- UV Response of Mammalian p53 Tumor Supressor Gene
- High-Level Expression of Wild-Type p53 in Melanoma Cells is Frequently Associated with Inactivity in p53 Reporter Gene Assays
- Comprehensive analysis of the p53 status in mucosal and cutaneous melanomas
- Therapeutic Efficacy by Targeting Correction of Notch1-Induced Aberrants in Uveal Tumors
- Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.
- The novel tumour suppressor gene ING1 is overexpressed in human melanoma cell lines
- Primary malignant melanoma of the vulva An aggressive tumor for modeling the genesis of Non-UV light-associated melanomas
- Update on genetic events in the pathogenesis of melanoma
- p53 protein expression and TP53 mutations in malignant melanomas of sun-sheltered mucosal membranes versus chronically sun-exposed skin
- Expression and function of the apoptosis effector Apaf-1 in melanoma
- The TP53 Tumor Suppressor Gene and Melanoma Tumorigenesis: Is There a Relationship?
- c-Myc is able to sensitize human melanoma cells to diverse apoptotic triggers
- Progress in cutaneous cancer research.
- Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis
- Cell cycle in sporadic melanoma
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