Gradual selection of a cellular clone presenting a mutation at codon 179 of the p53 gene during establishment of the immortalized human breast epithelial cell line HMT-3522.
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Summary
The occurrence of a p53 mutation along passages stored as frozen vials during establishment of a nontumorigenic human mammary epithelial cell line HMT-3522 was studied, indicating that the mutation was preexisting in passage 30 and gradually selected out because of the growth advantage it conferred.
- Type
- article
- Published
- 1994-12-01
- Cited by
- 35
- References
- 0
- OpenAlex
- https://openalex.org/W2013229697
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24969808
Keywords
Biology, clone (Java method), Selection (genetic algorithm), Gene, Mutation
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