Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
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Summary
The results indicate that HIV-1 isolates exhibit differences in the ability to infect CD4+-T-cell subsets such as Th1 or Th2 cells and that this difference may partly correlate with the expression of particular chemokine receptors on these cells.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 54
- References
- 60
- OpenAlex
- https://openalex.org/W9847335
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41550382
Keywords
Medicine, First aid, Medical emergency, Family medicine, Pediatrics
References
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- The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism
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- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
- Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
- MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection
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- Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions
- Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages
- Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture
- Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.
- Syncytium-inducing HIV-1 variants replicate equally well in all types of T-helper cell clones.
- The expanding universe of T-cell subsets: Th1, Th2 and more.
- Sequential Determination of Viral Load and Phenotype in Human Immunodeficiency Virus Type 1 Infection
Cited by
- Interleukin-4-transgenic hu-PBL-SCID mice: a model for the screening of antiviral drugs and immunotherapeutic agents against X4 HIV-1 viruses.
- Toll‐like receptors, cytokines and HIV‐1
- Opposite Effects of IL-10 on the Ability of Dendritic Cells and Macrophages to Replicate Primary CXCR4-Dependent HIV-1 Strains1
- Bacterial Lipopolysaccharide Activates HIV Long Terminal Repeat Through Toll-Like Receptor 41
- Envelope-Dependent Restriction of Human Immunodeficiency Virus Type 1 Spreading in CD4+ T Lymphocytes: R5 but Not X4 Viruses Replicate in the Absence of T-Cell Receptor Restimulation
- Th2-Th1 shift with the multiantigenic formulation TERAVAC-HIV-1 in Balb/c mice.
- Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: environmental and constitutive factors.
- Immune privilege and HIV‐1 persistence in the CNS
- Increased Levels of Circulating Cytokines with HIV-Related Immunosuppression
- Interleukin (IL)-4 inhibits phorbol-ester induced HIV-1 expression in chronically infected U1 cells independently from the autocrine effect of endogenous tumour necrosis factor-alpha, IL-1beta, and IL-1 receptor antagonist.
- Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.
- Selective Transmission of R5 HIV-1 over X4 HIV-1 at the Dendritic Cell–T Cell Infectious Synapse Is Determined by the T Cell Activation State
- Enhanced infectivity of HIV-1 by X4 HIV-1 coinfection.
- Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins
- Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes.
- Inhibitory and enhancing effects of IFN-gamma and IL-4 on SHIV(KU) replication in rhesus macaque macrophages: correlation between Th2 cytokines and productive infection in tissue macrophages during late-stage infection.
- Increased in vitro replication of CC chemokine receptor 5-restricted human immunodeficiency virus type 1 primary isolates in Th2 lymphocytes may correlate with AIDS progression
- Identification and characterization of differentially expressed mRNAs in HIV type 1-infected human T cells.
- Interleukin‐4 Up‐Regulates T‐Tropic Human Immunodeficiency Virus Type 1 Transcription in Primary CD4+ CD38+ T‐Lymphocyte Subset
- Resting CD4(+) T cells with CD38(+)CD62L(+) produce interleukin-4 which contributes to enhanced replication of T-tropic human immunodeficiency virus type 1.
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