Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.
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Summary
The data indicate that HIV replication occurs predominantly in Th1 cells and is associated with immune activation and up-regulation of Bcl-2, conferring a considerable degree of protection against apoptosis in the productively infected subpopulation.
- Type
- article
- Published
- 2004-06-15
- Cited by
- 38
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1997322837
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21504286
Keywords
Biology, Chemokine, IL-2 receptor, Cytokine, Chemokine receptor
References
- T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)- mediated apoptosis of CD4+ T cells from human immunodeficiency virus- infected persons
- Induction of HIV-1 Replication by Type 1-Like Cytokines, Interleukin (IL)-12 and IL-15: Effect on Viral Transcriptional Activation, Cellular Proliferation, and Endogenous Cytokine Production
- Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
- Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication.
- Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells
- The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle
- Up-Regulation of CCR5 and CCR6 on Distinct Subpopulations of Antigen-Activated CD4+ T Lymphocytes1
- In Vivo Pathogenesis of a Human Immunodeficiency Virus Type 1 Reporter Virus
- Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines
- IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection: correlation with its ability to block culture-induced down-modulation of Bcl-2.
- Decreased Stimulation of CD4+ T Cell Proliferation and IL-2 Production by Highly Enriched Populations of HIV-Infected Dendritic Cells
- Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.
- Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.
- CCR5 and CXCR4 Expression on Memory and Naive T Cells in HIV‐1 Infection and Response to Highly Active Antiretroviral Therapy
- Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1.
- Expression Patterns of the HIV Type 1 Coreceptors CCR5 and CXCR4 on CD4+ T Cells and Monocytes from Cord and Adult Blood
- Enhanced HIV expression during Th2‐oriented responses explained by the opposite regulatory effect of IL‐4 and IFN‐γ on fusin/CXCR4
- Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.
- Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease
- Endogenous cytokine production protects T cells from spontaneous apoptosis during highly active antiretroviral therapy
Cited by
- Charakterisierung zellulärer Immunantworten von mit SIV immunisierten und infizierten Makaken
- Molecular and immunogenic analysis of Jembrana disease virus Tat
- Claudin‐2 downregulation by KSHV infection is involved in the regulation of endothelial barrier function
- Dendritic cell-mediated HIV-1 transmission
- Immune privilege and HIV‐1 persistence in the CNS
- HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response.
- HIV-infection of CD4+ T-cells enhances their effectiveness against hepatocytes infected with malaria parasites.
- The activation and dynamics of cytokine expression by CD4+ T cells and AIDS progression in HIV-1-infected Chinese individuals.
- Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo.
- HIV Infection of Primary CD4+ Th2 Cells, Defined by Expression of The Chemoattractant Receptor-Homologous (CRTH2), Induces A Th0 Phenotype
- Surfactant Protein D Inhibits HIV-1 Infection of Target Cells via Interference with gp120-CD4 Interaction and Modulates Pro-Inflammatory Cytokine Production
- The impact of pregnancy on the HIV-1-specific T cell function in infected pregnant women.
- Immunophenotypic alterations in acute and early HIV infection.
- Mucosal Immunology of HIV Infection
- IL-10-secreting T cells from HIV-infected pregnant women downregulate HIV-1 replication: effect enhanced by antiretroviral treatment
- Short communication: HIV antigen-specific reactivation of HIV infection from cellular reservoirs: implications in the settings of therapeutic vaccinations.
- Functional genomics analyses of differential macaque peripheral blood mononuclear cell infections by human immunodeficiency virus-1 and simian immunodeficiency virus.
- Toll-like receptor and chemokine receptor expression in HIV-infected T lymphocyte subsets.
- Lysis of Endogenously Infected CD4+ T Cell Blasts by rIL-2 Activated Autologous Natural Killer Cells from HIV-Infected Viremic Individuals
- Mechanism and history of evolution of symbiotic HIV strains into lethal pandemic strains: the key event may have been a 1927 trial of pamaquine in Leopoldville (Kinshasa), Congo.
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