High-density multiplex detection of nucleic acid sequences: oligonucleotide ligation assay and sequence-coded separation.
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Summary
A non-isotopic, semi-automated method for large-scale multiplex analysis of nucleic acid sequences, using the cystic fibrosis transmembrane regulator (CFTR) gene as an example, which is especially useful for allelic discrimination in highly polymorphic genes such as CFTR.
- Type
- article
- Published
- 1994-10-25
- Cited by
- 143
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W7526344
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11255453
Keywords
Business
References
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- Development of a sensitive diagnostic multiplex platform based on digitally encoded microcarriers
- An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs
- ProbeMaker: an extensible framework for design of sets of oligonucleotide probes
- Development and Validation of the AmpFℓSTR® MiniFilerTM PCR Amplification Kit: A MiniSTR Multiplex for the Analysis of Degraded and/or PCR Inhibited DNA *
- Introduction to PCR/OLA/SCS, a Multiplex DNA Test, and Its Application to Cystic Fibrosis
- Microfluidic bead-based methods for DNA analysis
- New technologies for genetic analysis in research and diagnostics settings
- Genetic variation in genes involved in Abeta-degradation in Alzheimer disease
- SNP genotyping by multiplexed solid-phase amplification and fluorescent minisequencing.
- Measurement of Na+/K+-ATPase activity with an automated analyzer.
- Medical Biomethods Handbook
- Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation.
- Detecting CFTR gene mutations by using primer oligo base extension and mass spectrometry.
- Selection of a Platform for Mutation Detection
- PCR-oligonucleotide ligation assay from dried blood spots.
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