Arsenic-induced axial skeletal (dysraphic) disorders.
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Summary
In situ conversion of inorganic arsenic to methylated metabolites represents a detoxication pathway for both the dam and the developing embryo and suggests that arsenic-induced damage to the paraxial mesoderm may be related to the ultimate skeletal malformations.
- Type
- article
- Published
- 1981-04-01
- Cited by
- 59
- References
- 32
- OpenAlex
- https://openalex.org/W6894125
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7253014
Keywords
Agricultural science, Business, Biology
References
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- The teratogenic profile of sodium arsenate in the golden hamster.
- Methylated Forms of Arsenic in the Environment
- Malformations induced by sodium arsenate.
- Metabolism of orally administered inorganic arsenic in the dog
- Metabolism of inorganic arsenic (74As) in humans following oral ingestion.
- Inhibition of mitochondrial energy-linked functions by arsenate. Evidence for a nonhydrolytic mode of inhibitor action.
- Teratogenic effects of sodium arsenate in mice.
- Biomethylation of inorganic arsenic by the rat and some laboratory animals
- Separation of arsenic metabolites in dog plasma and urine following intravenous injection of 74As.
- Radioarsenic in plasma, urine, normal tissues, and intracranial neoplasms; distribution and turnover after intravenous injection in man.
Cited by
- Effects of meso-2,3-dimercaptosuccinic acid (DMSA) on the teratogenicity of sodium arsenate in mice
- Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration.
- Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?
- Lewisite: its chemistry, toxicology, and biological effects.
- Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 2. Acute exposure.
- Prenatal and developmental toxicology of arsenicals.
- Evaluation of a transgenic zebrafish model for assessing arsenic toxicity
- An assessment of the developmental toxicity of inorganic arsenic.
- Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model.
- Developmental analysis of cephalic axial dysraphic disorders in arsenic-treated hamster embryos
- Arsenic distribution and neurochemical effects in peroral sodium arsenite exposure of rats
- Evaluation of arsenic metabolites for prenatal effects in the hamster
- Arsenite Exposure Compromises Early Embryonic Development in the Golden Hamster
- Appropriate use of animal models in the assessment of risk during prenatal development: an illustration using inorganic arsenic.
- Evaluation of the effect of BAL (2,3-dimercaptopropanol) on arsenite-induced teratogenesis in mice.
- Arsenic-induced exencephaly in the mouse and associated lesions occurring during neurulation.
- Teratogenic response to arsenite during neurulation: relative sensitivities of C57BL/6J and SWV/Fnn mice and impact of the splotch allele.
- Maternal toxicity and the identification of inorganic arsenic as a developmental toxicant.
- Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration.
- Effects of dietary boron and arsenic on the behavior of mallard ducklings
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