IL-1β Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs
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Summary
It is shown that incubating human monocytes with NCX-4016 causes intracellular NO formation and suppresses IL-1β and IL-18 processing by inhibiting caspase-1 activity, a new, cycloxygenase-independent antiinflammatory mechanism of NO-aspirin.
- Type
- article
- Published
- 2000-11-01
- Cited by
- 99
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1909194257
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21428467
Keywords
Nitric oxide, Chemistry, Pharmacology, Proinflammatory cytokine, Intracellular
References
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- Nitric oxide‐releasing NSAIDs inhibit interleukin‐1β converting enzyme‐like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα
- Prognostic value of Th1/Th2 ratio in rheumatoid arthritis.
- Human ICE/CED-3 protease nomenclature.
- A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats.
- Nitric Oxide Inhibits Caspase-3 by S-Nitrosationin Vivo *
- The L-arginine: nitric oxide pathway.
- Caspases
- Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats.
- Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated.
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.
Cited by
- NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
- Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
- Anti-inflammatory agents as cancer therapeutics.
- Caspase inhibitors as anti-inflammatory and antiapoptotic agents.
- Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport.
- Recent developments in nitric oxide donor drugs
- Inflammasome activation of IL-1 family mediators in response to cutaneous photodamage
- New xanthone derivatives as potent anti-inflammatory agents.
- A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1β Processing in Human Monocytes1
- Nitric Oxide Regulates Immune Cell Bioenergetic: A Mechanism to Understand Immunomodulatory Functions of Nitric Oxide-Releasing Anti-Inflammatory Drugs
- NCX 4040, a nitric oxide-donating aspirin derivative, inhibits Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages.
- Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action
- Inhibition of Nuclear Factor-κB by a Nitro-Derivative of Flurbiprofen: A Possible Mechanism for Antiinflammatory and Antiproliferative Effect
- Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
- Tissue factor and nitric oxide: a controversial relationship!
- Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders.
- Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis.
- NO-aspirin: mechanism of action and gastrointestinal safety.
- Comparative effects of aspirin and NO-releasing aspirins on differentiation, maturation and function of human monocyte-derived dendritic cells in vitro.
- Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide‐releasing derivative, nitroflurbiprofen, on prostaglandin E2, interleukin‐1β, and nitric oxide synthesis by activated microglia
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