IL-1β Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs

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Summary

It is shown that incubating human monocytes with NCX-4016 causes intracellular NO formation and suppresses IL-1β and IL-18 processing by inhibiting caspase-1 activity, a new, cycloxygenase-independent antiinflammatory mechanism of NO-aspirin.

Type
article
Published
2000-11-01
Cited by
99
References
57
Access
Open access

Keywords

Nitric oxide, Chemistry, Pharmacology, Proinflammatory cytokine, Intracellular

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