HTLV-1 Yin and Yang: Rex and p30 Master Regulators of Viral mRNA Trafficking
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Summary
In human T-cell lymphotropic virus type 1, Rex and p30 are both nuclear/nucleolar RNA binding regulatory proteins that orchestrate virus replication and ensure vigilant control of viral gene expression.
- Type
- review
- Published
- 2008-10-01
- Cited by
- 41
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W2698158
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25078981
Keywords
Messenger RNA, Cell biology, Biology, Virology, Computational biology
References
- PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner
- Functional architecture in the cell nucleus.
- Current views in HTLV‐I‐associated adult T‐cell leukemia/lymphoma
- The 5' coding sequence of IL-2 receptor alpha chain mRNA mediates mRNA stabilization by HTLV-1 Rex.
- Roles of viral and cellular proteins in the expression of alternatively spliced HTLV-1 pX mRNAs.
- The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein.
- Identification of a signal for rapid export of proteins from the nucleus.
- Transcriptional and post-transcriptional gene regulation of HTLV-1
- Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-I Rex transactivator
- HBZ, a new important player in the mystery of adult T-cell leukemia.
- RNA viruses: hijacking the dynamic nucleolus
- The HTLV-I orfI protein is recognized by serum antibodies from naturally infected humans and experimentally infected rabbits.
- The cauliflower mosaic virus translational transactivator interacts with the 60S ribosomal subunit protein L18 of Arabidopsis thaliana.
- HTLV-I associated myelopathy, a new clinical entity.
- A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo.
- The multifunctional nucleolus
- Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).
- Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein
- Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
- X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro.
Cited by
- The multifaceted oncoprotein Tax: subcellular localization, posttranslational modifications, and NF-κB activation.
- Regulation of Human T-cell Leukemia Virus Type 1 Infection and Replication
- Epidemiología molecular del virus linfotrópico T-humano tipo 1 (HTLV-1) en Argentina: análisis étnico-geográfico y variabilidad viral
- Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress
- The Battle between Virus and Host: Modulation of Toll-Like Receptor Signaling Pathways by Virus Infection
- Mechanisms of HTLV-1 persistence and transformation
- Role of HTLV-1 p30 during infection of monocytes and dendritic cells
- Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4
- Hijacking the T-cell Communication Network by the Human T-cell Leukemia/Lymphoma Virus Type 1 (HTLV-1) p12 and p8 Proteins
- HTLV gene regulation: because size matters, transcription is not enough.
- Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication.
- Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis
- Viral Proteins Originated De Novo by Overprinting Can Be Identified by Codon Usage: Application to the “Gene Nursery” of Deltaretroviruses
- Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.
- Interrelationship Between Cytoplasmic Retroviral Gag Concentration and Gag-Membrane Association
- HTLV-1 Rex: the courier of viral messages making use of the host vehicle
- HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression
- Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence
- Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis
- The role of small non-coding RNAs in human T-cell leukemia virus type 1 (HTLV-1) infection and transformation
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