Nifedipine has paradoxical effects on the development of kindling but not on kindled seizures in amygdala-kindled rats.
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Summary
Results suggested that although nifedipine inhibited the propagation processes of seizures during development of kindling, it appeared to increase the duration of epileptic activity at the kindling focus.
- Type
- article
- Published
- 1991-05-01
- Cited by
- 17
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W1865996
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38397742
Keywords
Medicine, Food science, Chemistry
References
- Autoradiographic visualization of [3H]nitrendipine binding sites in rat brain: localization to synaptic zones.
- Evidence for down-regulation of 3H-nitrendipine recognition sites in mouse brain after long-term treatment with nifedipine or verapamil.
- Development of Epileptic Seizures through Brain Stimulation at Low Intensity
- A permanent change in brain function resulting from daily electrical stimulation.
- Central effects of Ca2+ antagonists
- Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures.
- Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker.
- Inhibition of radioligand binding to A1 adenosine receptors by Bay K8644 and nifedipine.
- Is Adenosine an Endogenous Anticonvulsant?
- Cumulative after-discharge as the principal factor in the acquisition of kindled seizures.
- Fast extracellular calcium transients: involvement in epileptic processes.
- The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists.
- Effect of various calcium channel blockers on three different models of limbic seizures in rats.
- In vivo identification of calcium antagonist binding sites using [3H]nitrendipine.
- Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy.
- Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
- Nifedipine for epilepsy? A pilot study
- Antiepileptic Effects of a Calcium Antagonist (Nimodipine) on Cefazolin‐Induced Epileptogenic Foci in Rabbits
- Dihydropyridines modulate K+-evoked amino acid and adenosine release from cerebellar neuronal cultures.
- The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures.
Cited by
- Effects of nifedipine on rhythmic synchronous activity of human neocortical slices.
- Flunarizine--its effect on pentylenetetrazol-kindled seizures and on related cognitive disturbances.
- Voltage‐Activated Calcium Channels: Targets of Antiepileptic Drug Therapy?
- Contribution of T-type calcium channels to afterdischarge generation in rat hippocampal slices.
- Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats.
- Psychopharmacological properties of calcium channel inhibitors
- Chronic low‐dose maternal exposure to methylmercury enhances epileptogenicity in developing rats
- Opposite effects of ethanol and nitrendipine on nicotine-induced emesis and convulsions.
- Ifenprodil and arcaine alter amygdala-kindling development.
- Calcium Channel Blockers Verapamil and Nimodipine Inhibit Kindling in Adult and Immature Rats
- Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices.
- Effect Of Isradipine On MES And Picrotoxin Induced Convulsion
- EFFECT OF ISRADIPINE ON MES AND PICROTOXIN INDUCED CONVULSION DEVI.K * AND KAVIMANI.S
- The Effect of the Voltage-Gated Calcium Channel Blocker, Nifedipine, on Kindling and Kindling-Induced Mossy Fibre Sprouting
- Antidepressants
- PHARMACOGNOSTICAL EVALUATION AND ANTICONVULSANT ACTIVITY OF STEM OF ABUTILON INDICUM LINN SWEET
- Calcium Channel Antagonists in Mood Disorders
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