Mutational heterogeneity in cancer and the search for new cancer genes
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Summary
A fundamental problem with cancer genome studies is described; as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds and a novel analytical methodology is provided, MutSigCV, for resolving the problem.
- Published
- 2014-01-01
- Cited by
- 2,105
- References
- 30
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4302761
References
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- The landscape of cancer genes and mutational processes in breast cancer
- Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- Frequent mutation of histone modifying genes in non-Hodgkin lymphoma
- Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions
- Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects
- Patterns of somatic mutation in human cancer genomes
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions
- Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
- Human mutation rate associated with DNA replication timing
- Initial genome sequencing and analysis of multiple myeloma
- Variation in the mutation rate across mammalian genomes
- Differential relationship of DNA replication timing to different forms of human mutation and variation.
- Integrated Genomic Analyses of Ovarian Carcinoma
- Mutational Processes Molding the Genomes of 21 Breast Cancers
- A small cell lung cancer genome reports complex tobacco exposure signatures
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