The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms
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Summary
A narrative review of the ways in which microbiota might affect the aging process and age-related cognitive decline finds that not only gut microbiota, but also microbiota colonizing the oral cavity may be associated with age-related neurodegenerative diseases.
- Type
- review
- Published
- 2025-02-01
- Cited by
- 11
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W4407528359
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:276383648
Keywords
Narrative, Cognitive decline, Narrative review, Cognition, Biology
References
- The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia
- Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue
- Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
- Immune responses to gut microbiota-commensals and pathogens
- Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
- The role of the adaptive immune system in regulation of gut microbiota
- Central nervous system pericytes in health and disease
- The gut microbiome in health and in disease
- Interactions between the microbiota and the immune system
- The Biologic Clock: The Mitochondria?
- Role of the Microbiota in Immunity and inflammation
- Defining the Normal Bacterial Flora of the Oral Cavity
- Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate
- Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-alpha exposure.
- Inflammatory markers in population studies of aging
- Biological Aging Is No Longer an Unsolved Problem
- Damage, DNA Repair, Aging, and Neurodegeneration
- Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line
- The healthy human microbiome
- Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly.
Cited by
- C-reactive protein-triglyceride glucose index and risk of cognitive decline in Chinese middle-aged and older adults: A 9-year national cohort study from CHARLS
- The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials
- The gut and circulating virome: emerging players in aging and longevity
- The brain–bone–gut axis: a microbial bridge underlying multisystem comorbidities
- A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice
- Microbiota-driven neuroimmune mechanisms in brain disorders: Microglial activation, cytokine signaling, and translational implications.
- Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6
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