Hallmarks of aging: An expanding universe.
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Summary
This work proposes the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis.
- Type
- review
- Published
- 2022-12-26
- Cited by
- 5,317
- References
- 298
- OpenAlex
- https://openalex.org/W4313531093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:255394876
Keywords
Biology, Proteostasis, Telomere, Epigenetics, Genome instability
References
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- Meta-hallmarks of aging and cancer.
- Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy
- The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging
- Bodywide ecological interventions on cancer
- Single cell DNA methylation ageing in mouse blood
- Cellular senescence and the host immune system in aging and age-related disorders
- Implication of Cellular Senescence in Osteoarthritis: A Study on Equine Synovial Fluid Mesenchymal Stromal Cells
- From Cue to Meaning: The Involvement of POLD1 Gene in DNA Replication, Repair and Aging.
- A kinetic dichotomy between mitochondrial and nuclear gene expression drives OXPHOS biogenesis
- Progress in Discovering Transcriptional Noise in Aging
- Role of cellular senescence in inflammatory lung diseases.
- Discovery of A New Hereditary RECQ Helicase Disorder RECON Syndrome Positions the Replication Stress Response and Genome Homeostasis as Centrally Important Processes in Aging and Age-Related Disease
- Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates
- The Molecular and Cellular Basis of Hutchinson–Gilford Progeria Syndrome and Potential Treatments
- Mitochondrial stress and aging: Lessons from C. elegans.
- Sex differences in markers of oxidation and inflammation. Implications for ageing.
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