Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

Keywords

Biology, Longevity, mTORC1, Carcinogenesis, Sirolimus

References

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• Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potentialZoya N. Demidenko, Mikhail V. Blagosklonny — 2009
• mTOR's role in ageing: protein synthesis or autophagy?Sarah Hands, Christopher G. Proud, Andreas Wyttenbach — 2009
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• The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1Gino Heeren, Mark Rinnerthaler, Peter Laun — 2009
• Metformin and sex: why suppression of aging may be harmful to young male miceMikhail V. Blagosklonny — 2010
• Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated MiceSvetlana V. Rosenfeld, E. F. Togo, V. S. Mikheev — 2002
• mTOR pathway activation in age-related retinal diseaseChen Zhao, Douglas Vollrath — 2011
• Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogasterAlexey Moskalev, Mikhail Shaposhnikov — 2010
• Paradoxical suppression of cellular senescence by p53Zoya N. Demidenko, Lioubov G. Korotchkina, Andrei V. Gudkov — 2010
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• Rapamycin and quasi-programmed aging: Four years laterMikhail V. Blagosklonny — 2010
• Growth stimulation leads to cellular senescence when the cell cycle is blockedZoya N. Demidenko, Mikhail V. Blagosklonny — 2008
• Fighting neurodegeneration with rapamycin: mechanistic insightsJordi Bové, Marta Martínez‐Vicente, Miquel Vila — 2011
• Prevention of cancer by inhibiting agingMikhail V. Blagosklonny — 2008
• Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespanColin Selman, Jennifer M. A. Tullet, Daniela Wieser — 2009
• Metformin Decelerates Aging and Development of Mammary Tumors in HER-2/neu Transgenic MiceVladimir N. Anisimov, Peter A. Egormin, Л. М. Берштейн — 2005
• Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic InhibitionMikhail V. Blagosklonny — 2006

Cited by

• Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or enduranceJames Rizzo — 2013
• Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer.Jonathan Cimino, Nor Eddine Sounni, David Calligaris — 2014
• Answering the ultimate question “What is the Proximal Cause of Aging?”Mikhail V. Blagosklonny — 2012
• Rapamycin Combined with Immature Dendritic Cells Attenuates Obliterative Bronchiolitis in Trachea Allograft Rats by Regulating the Balance of Regulatory and Effector T CellsJosé Carlos Erdozaín López — 2015
• Rapamycin, proliferation and geroconversion to senescenceYiannakis Sazeides, James E. Smith — 2018
• M(o)TOR of aging: MTOR as a universal molecular hypothalamusMikhail V. Blagosklonny — 2013
• ANALYSIS OF THE ROLE OF TWO AUTOPHAGY PATHWAY RELATED GENES, BECN1 AND TSC1, IN MURINE MAMMARY GLAND DEVELOPMENT AND DIFFERENTIATIONAmber N. Hale — 2014
• Mouse models and aging: longevity and progeria.Chen‐Yu Liao, Brian K. Kennedy — 2014
• The role of telomerase in brain during ageing and under dietary restrictionRafal Czapiewski — 2013
• Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout LifeKathleen E. Fischer, Jonathan Gelfond, Vanessa Soto‐Cerrato — 2015
• SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegansT. Keith Blackwell, Michael J. Steinbaugh, John M Hourihan — 2015
• Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug?Vladimir N. Anisimov — 2015
• Rapamycin increases oxidative stress response gene expression in adult stem cellsAmber E. Kofman, Margeaux R. McGraw, Christopher J. Payne — 2012
• Once again on rapamycin-induced insulin resistance and longevity: despite of or owing toMikhail V. Blagosklonny — 2012
• Molecular damage in cancer: an argument for mTOR-driven agingMikhail V. Blagosklonny — 2011
• One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metforminJavier A. Menéndez, Jorge Joven — 2012
• Rejuvenating immunity: “anti-aging drug today” eight years laterMikhail V. Blagosklonny — 2015
• Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated agingOlga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny — 2012
• Herbal Therapeutics that Block the Oncogenic Kinase PAK1: A Practical Approach towards PAK1‐dependent Diseases and LongevityHiroshi Maruta — 2014
• NCI's provocative questions on cancer: some answers to ignite discussionMikhail V. Blagosklonny — 2011

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