Regulation of Fibronectin by Platelet-Derived Growth Factors in Cultured Rat Thoracic Aortic Smooth Muscle Cells.

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Summary

Induction of fibronectin gene expression by platelet-derived growth factor (PDGF) isoforms in rat thoracic aortic smooth muscle cells (SMC) was examined and showed that PDGF-BB enhances FN levels in SMC cultures in a time- and concentration-response fashion, implying that acquisition of additional FN mRNA units accounts for the increase in FN levels.

Type
article
Published
1995-01-01
Cited by
5
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0

Keywords

Platelet-derived growth factor receptor, Fibronectin, Platelet-derived growth factor, Growth factor, Extracellular matrix

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