Long Noncoding RNA SLC20A1-1 Induces Nucleus Pulposus Apoptosis by Sponging miR-146a-5p
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Summary
Overexpression of SLC20A1-1 inhibited NPC growth, promoted NPC apoptosis, and enhanced macrophage recruitment and migration, and the effect of SLC20A1-1 on NPCs and macrophages could be reversed by etanercept treatment.
- Type
- article
- Published
- 2022-03-01
- Cited by
- 2
- References
- 16
- OpenAlex
- https://openalex.org/W4220769238
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:247791884
Keywords
Apoptosis, Flow cytometry, Tumor necrosis factor alpha, Downregulation and upregulation, Long non-coding RNA
References
- Direct Application of the Tumor Necrosis Factor-&agr; Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons
- Role of Cytokines in Intervertebral Disc Degeneration: Pain and Disc-content
- Unique features of long non-coding RNA biogenesis and function
- Intervertebral Disk Degeneration and Repair
- Accumulation and Localization of Macrophage Phenotypes with Human Intervertebral Disc Degeneration
- The functions and unique features of long intergenic non-coding RNA
- Emerging roles of non-coding RNAs in the pathogenesis, diagnosis and prognosis of osteosarcoma
- Effect of NF-kB signaling pathway on the expression of MIF, TNF-α, IL-6 in the regulation of intervertebral disc degeneration
- Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen.
- Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration
- MiR-146a-5p inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells by regulating NF-κB signaling pathway.
- MiR-146a-5p promotes IL-1β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway
- Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model
- The role of IL-1β and TNF-α in intervertebral disc degeneration.
- microRNA functions.
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