eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale
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Summary
A major upgrade to eggNOG-mapper, a tool for functional annotation based on precomputed orthology assignments, now optimized for vast (meta)genomic data sets, is described.
- Type
- letter
- Published
- 2021-06-03
- Cited by
- 4,320
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W3203343200
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:235348928
Keywords
Annotation, Biology, Metagenomics, Contig, Computational biology
References
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- The Gene Ontology Resource: 20 years and still GOing strong
- Advances and Applications in the Quest for Orthologs
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- A unified catalog of 204,938 reference genomes from the human gut microbiome
- DRAM for distilling microbial metabolism to automate the curation of microbiome function
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- The InterPro protein families and domains database: 20 years on
- Pfam: The protein families database in 2021
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- UniProt: the universal protein knowledgebase in 2021
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- Experimental and computational investigation of enzyme functional annotations uncovers misannotation in the EC 1.1.3.15 enzyme class
- Accurate annotation of protein coding sequences with IDTAXA
- Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter
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- Bacterial growth in multicellular aggregates leads to the emergence of complex lifecycles
- MRGM: a mouse reference gut microbiome reveals a large functional discrepancy for gut bacteria of the same genus between mice and humans
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