Early life stress induces dysregulation of the heme pathway in adult mice
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Summary
It is proposed that ELS induces increased circulating heme through dysregulation of the haptoglobin‐hemoglobin system representing a mechanistic link between ELS and CVD risk in adulthood.
- Type
- article
- Published
- 2021-05-01
- Cited by
- 3
- References
- 77
- Access
- Open access
- OpenAlex
- https://openalex.org/W3165136282
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:235217132
Keywords
Hemopexin, Heme, Haptoglobin, Hemoglobin, Endocrinology
References
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- Haemopexin affects iron distribution and ferritin expression in mouse brain
- Chronic Restraint Stress Upregulates Erythropoiesis through Glucocorticoid Stimulation
- Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.
- Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
- Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety
- Heme Degradation by Reactive Oxygen Species
- Mechanisms of Disease: Toll-like receptors in cardiovascular disease
- Early Life Activation of Toll-Like Receptor 4 Reprograms Neural Anti-Inflammatory Pathways
- A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood
- Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.
- Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet.
Cited by
- Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
- Influence of Diet on Reproducible Corticosterone Levels in a Mouse Model of Maternal Separation with Early Weaning
- Early Life Stress Induces Brain Mitochondrial Dynamics Changes and Sex‐Specific Adverse Effects in Adulthood
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