Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
Explore this paper's citation graph
Summary
The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
- Type
- review
- Published
- 2006-04-01
- Cited by
- 2,340
- References
- 824
- OpenAlex
- https://openalex.org/W2005904261
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12219718
Keywords
Biliverdin, Heme, Heme oxygenase, Nitric oxide, Bilirubin
References
- Rat lung metallothionein and heme oxygenase gene expression following ozone and zinc oxide exposure.
- Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
- The heat shock response.
- Biliverdin as an electron transfer catalyst for superoxide ion in aqueous medium
- Stress protein systems of mammalian cells.
- Function and induction of the microsomal heme oxygenase
- A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats.
- Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation.
- The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors.
- Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3.
- Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.
- Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes.
- "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999.
- Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine.
- Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide.
- Midkine: a potential bridge between glucocorticoid and retinoid effects on lung vascular development.
- Carbon monoxide and the nervous system.
- Methods for measurements of heme oxygenase (HO) isoforms-mediated synthesis of carbon monoxide and HO-1 and HO-2 proteins.
- Transcriptional regulation by the MAP kinase signaling cascades.
- The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury.
Cited by
- Unraveling the Role of Hemeoxygenase-1/Carbon Monoxide in Pulmonary and Cardiovascular Diseases.
- Heme-oxygenase induction inhibits arteriolar thrombosis in vivo: effect of the non-substrate inducer cobalt protoporphyrin.
- Carbon Monoxide: Vascular Therapeutic for the Future
- Ion channels as effectors in carbon monoxide signaling
- Redox regulation of gamma-glutamyl transpeptidase.
- Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction
- Carbon monoxide reverses diabetic gastroparesis in NOD mice.
- Heme oxygenase-1 in inflammation and cardiovascular disease.
- Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis.
- Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer.
- The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1.
- Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells.
- Carboxyhemoglobin levels in medical intensive care patients
- Protective effect of Withania somnifera against radiation-induced hepatotoxicity in rats.
- Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis.
- Effects of heme oxygenase‐1 on bacterial antigen‐induced articular chondrocyte catabolism in vitro
- Heme oxygenase-1 activity is involved in the control of Toxoplasma gondii infection in the lung of BALB/c and C57BL/6 and in the small intestine of C57BL/6 mice
- Penicillinolide A: A New Anti-Inflammatory Metabolite from the Marine Fungus Penicillium sp. SF-5292
- Ethyl Acetate Extract of Artemisia anomala S. Moore Displays Potent Anti-Inflammatory Effect
- Carbon monoxide and the CNS: challenges and achievements
Related papers
- Heme Oxygenase: Who Needs It? (44455)
- Heme Oxygenase: Who Needs It?
- Antioxidant Activities of Bile Pigments
- Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 in human and pig gastric fundus.
- Control of Heme Oxygenase and Plasma Levels of Bilirubin by a Synthetic Heme Analogue, Tin‐Protoporphyrin
- Recent advances in the vascular pathophysiology of heme oxygenase–carbon monoxide system
- The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis.