The Mechanism of Compound Danshen Dripping Pills in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking
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Summary
core active components of CDDP, mainly including Asiatic acid and Salvianolic acid j, may play a role in regulating cell proliferation and response to inflammation and hypoxia by regulating the binding and recognition of intracellular and extracellular proteins, that is, mainly through TNF signaling pathway and HIF-1 signaling pathway.
- Type
- preprint
- Published
- 2021-05-07
- Cited by
- 0
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W3164508606
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:236604522
Keywords
DrugBank, PubChem, KEGG, AutoDock, Panax notoginseng
References
- The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXII. The Twenty-Five-Year Progression of Retinopathy in Persons with Type 1 Diabetes
- High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes.
- High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy.
- Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study.
- Diabetic Retinopathy: Vascular and Inflammatory Disease
- Developmental expression and corticosterone inhibition of adenosine deaminase activity in different tissues of mice.
- Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus
- Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt vs Deferred Laser Treatment: 3-year Randomized Trial Results
- Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes.
- The impact of diabetic retinopathy: understanding the patient's perspective
- Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy.
- DrugBank: a knowledgebase for drugs, drug actions and drug targets
- Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy
- Heritability of the Severity of Diabetic Retinopathy: The FIND-Eye Study
- Prevention of blindness by screening for diabetic retinopathy: a quantitative assessment.
- TTD: Therapeutic Target Database
- Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients
- The role of vascular endothelial growth factor, tumor necrosis factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy.
- Diabetes-induced Activation of Nuclear Transcriptional Factor in the Retina, and its Inhibition by Antioxidants
- Inflammation in neurodegenerative diseases – an update
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