Metabolic profiling in human SH-SY5Y neuronal cells exposed to perfluorooctanoic acid (PFOA).
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Summary
This study generates mechanistic knowledge regarding PFOA-induced neurotoxicity, focusing on mitochondrial oxidative respiration and the neuronal metabolome, and hypothesize that this metabolic signature may be associated with the reduced mitochondrial membrane potential observed at lower P FOA concentrations.
- Type
- article
- Published
- 2021-05-21
- Cited by
- 45
- References
- 47
- OpenAlex
- https://openalex.org/W3164084350
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:235199517
Keywords
Perfluorooctanoic acid, SH-SY5Y, Viability assay, Chemistry, Reactive oxygen species
References
- Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry.
- SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.
- Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions.
- Perfluorinated compounds--exposure assessment for the general population in Western countries.
- Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity.
- Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples
- Chronic Exposure to Perfluorooctane Sulfonate Induces Behavior Defects and Neurotoxicity through Oxidative Damages, In Vivo and In Vitro
- Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells.
- Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells
- Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors.
- Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey
- Acetyl-L-Carnitine Modulates TP53 and IL10 Gene Expression Induced by 3-NPA Evoked Toxicity in PC12 Cells
- Perfluorinated acids in air, rain, snow, surface runoff, and lakes: relative importance of pathways to contamination of urban lakes.
- Human serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in Uyghurs from Sinkiang-Uighur Autonomous Region, China: background levels study
- Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro
- Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices.
- Perfluorinated compounds in tap water from China and several other countries.
- Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: a proteomic study.
- Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice.
- Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in surface waters, sediments, soils and wastewater - A review on concentrations and distribution coefficients.
Cited by
- Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish.
- Perfluorooctanoic Acid (PFOA) Induces Redox Status Disruption in Swine Granulosa Cells
- Associations of serum perfluoroalkyl substances with concentrations of blood manganese and selenium
- The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: focus on organic pollutants.
- Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy
- Insights into the per- and polyfluoroalkyl substances-contaminated paper mill processing discharge: Detection, phytotoxicity, bioaccumulative profiling, and health risk verification
- Associations between concentrations of serum α-klotho and selected urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons: data for US adults aged 40–79 years
- Short-chain per- and polyfluoralkyl substances (PFAS) effects on oxidative stress biomarkers in human liver, kidney, muscle, and microglia cell lines.
- Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure.
- Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae.
- A systematic review on distribution, sources and sorption of perfluoroalkyl acids (PFAAs) in soil and their plant uptake.
- Perfluorooctanoic acid induces behavioral impairment and oxidative injury in Nauphoeta cinerea nymphs
- Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism.
- Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins.
- Maximizing the Role of Parents Through Religious Education in the Family in the Scope of Early Childhood Education
- Differential regulations of neural activity and survival in primary cortical neurons by PFOA or PFHpA.
- Understanding PFAS toxicity through cell culture metabolomics: Current applications and future perspectives.
- Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y).
- Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review
- Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort
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