Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions.
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Summary
The dopamine concentration and metabolism seem to be more sensitive against PFOS toxicity in the hippocampus than in the other analyzed brain areas, suggesting that the observed alterations on the dopamine system induced by PFOS could be a possible neurotoxicity mechanism of PFOS, leading to many neurological diseases.
- Type
- article
- Published
- 2016-01-05
- Cited by
- 52
- References
- 72
- OpenAlex
- https://openalex.org/W1914863002
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205448239
Keywords
Dopamine, Homovanillic acid, Dopaminergic, 3,4-Dihydroxyphenylacetic acid, Neurotoxicity
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Cited by
- The expression of several reproductive hormone receptors can be modified by perfluorooctane sulfonate (PFOS) in adult male rats.
- Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo
- Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances
- Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna.
- A Mixture of Persistent Organic Pollutants and Perfluorooctanesulfonic Acid Induces Similar Behavioural Responses, but Different Gene Expression Profiles in Zebrafish Larvae
- Endocrine-disrupting chemicals and the regulation of energy balance
- Perfluorooctane sulfonate (PFOS) can alter the hypothalamic-pituitary-adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors.
- Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior
- Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
- Blood metabolome signature predicts gut microbiome α-diversity in health and disease
- Modulation of Neuro-Dopamine Homeostasis in Juvenile Female Atlantic Cod ( Gadus morhua) Exposed to Polycyclic Aromatic Hydrocarbons and Perfluoroalkyl Substances.
- Neurodevelopmental and Metabolomic Responses from Prenatal Co-Exposure to Perfluorooctane Sulfonate (PFOS) and Methylmercury (MeHg) in Sprague-Dawley Rats.
- Association between perfluoroalkyl substance concentrations and blood pressure in adolescents.
- ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells.
- Blood metabolome predicts gut microbiome α-diversity in humans
- Perfluoroalkyl chemicals in neurological health and disease: Human concerns and animal models.
- Polybrominated diphenyl ether (PBDE) and poly- and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression
- Alteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing area.
- Assessing vesicular monoamine transport and toxicity using fluorescent false neurotransmitters
- Metabolic profiling in human SH-SY5Y neuronal cells exposed to perfluorooctanoic acid (PFOA).
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