One Hormone for Two Receptors: Exploring Glucocorticoid Actions Mediated by the Glucocorticoid and Mineralocorticoid Receptors
Explore this paper's citation graph
Summary
Results suggest a functional antagonism between GR and MR in which MR inhibits GR function, and the discovery of novel glucocorticoid-based therapeutics with minimal side effects is suggested.
- Type
- article
- Published
- 2021-05-03
- Cited by
- 0
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W3157862134
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:260569592
Keywords
Glucocorticoid receptor, Glucocorticoid, Mineralocorticoid, Nuclear receptor, Mineralocorticoid receptor
References
No references recorded for this paper.
Cited by
No citing papers recorded for this paper.
Related papers
- Isozymes of 11β-hydroxysteroid dehydrogenase: Which enzyme endows mineralocorticoid specificity?
- Mineralocorticoid selectivity: molecular and cellular aspects.
- Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.
- II-C-02 Reduced expression of excitatory amino acid transporter-2 (EAAT-2) and activation of microglia in the cerebral cortex of AIDS patients(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Postnatal handling alters glucocorticoid, but not mineralocorticoid messenger RNA expression in the hippocampus of adult rats.
- Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus.
- Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only.
- The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.
- Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health.