A model of active transcription hubs that unifies the roles of active promoters and enhancers.
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Summary
A universal pattern of promoter and enhancer distribution is found and a simple rule of spatial organization of active promoters and enhancers is proposed: Gene transcriptions and regulations mainly occur at local active transcription hubs contributed dynamically by multiple elements from linearly close enhancers and/or active promoters.
- Type
- article
- Published
- 2021-04-19
- Cited by
- 47
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W3156071777
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:233311019
Keywords
Enhancer, Promoter, Biology, Enhancer RNAs, Gene
References
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Cited by
- Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer
- Analysis of long and short enhancers in melanoma cell states
- Exploiting the mechanism of estrogen-induced transcription to fight breast cancer
- The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation
- Transcriptional enhancers and their communication with gene promoters
- Enhancer-promoter competition between homologous alleles leads to reduced transcription in early Drosophila embryos
- NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression
- Shared Transcriptional Machinery at Homologous Alleles Leads to Reduced Transcription in Early Drosophila Embryos
- Characterization of network hierarchy reflects cell state specificity in genome organization
- Deciphering multi-way interactions in the human genome
- Identifying enhancer-driven subtype-specific prognostic markers in breast cancer based on multi-omics data
- RNA out of the mist.
- Long non-coding RNAs: definitions, functions, challenges and recommendations
- The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation
- FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1
- Regulatory architecture of housekeeping genes is driven by promoter assemblies
- Epromoters are new players in the regulatory landscape with potential pleiotropic roles
- Genome-Wide Acetylation Modification of H3K27ac in Bovine Rumen Cell Following Butyrate Exposure
- NanoRanger enables rapid single base-pair resolution of genomic disorders
- Clustered and diverse transcription factor binding underlies cell type specificity of enhancers for housekeeping genes
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