The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: from antioxidant to epigenetic therapy.
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Summary
This review gives a comprehensive overview of the main mechanisms of action of RV in different experimental models, including clinical trials and discusses how the interconnection of these molecular events could explain the neuroprotective effects induced by RV.
- Type
- review
- Published
- 2021-02-08
- Cited by
- 178
- References
- 471
- Access
- Open access
- OpenAlex
- https://openalex.org/W3126884725
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:231848654
Keywords
Neuroprotection, Resveratrol, Disease, Cognitive decline, Neuroscience
References
- Clinical Evidence
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- The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation
- The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.
- Aging in the Brain: New Roles of Epigenetics in Cognitive Decline
- Effects of resveratrol pretreatment on endoplasmic reticulum stress and cognitive function after surgery in aged mice
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- Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches
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- Oxidative Stress in Neurodegenerative Diseases
- Mitochondrial dysfunction, oxidative stress and neurodegeneration
- Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms
- Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1
- Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats
Cited by
- Phytochemicals as Regulators of Genes Involved in Synucleinopathies
- Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease
- Mechanistic insight into the capacity of natural polar phenolic compounds to abolish Alzheimer's disease-associated pathogenic effects of apoE4 forms.
- Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice
- Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
- Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases
- Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging
- Lockdown of mitochondrial Ca2+ extrusion and subsequent resveratrol treatment kill HeLa cells by Ca2+ overload.
- Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer’s Disease
- Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice
- The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
- Phenolic compounds that cross the blood-brain barrier exert positive health effects as central nervous system antioxidants.
- Phenolic Characterization and Neuroprotective Properties of Grape Pomace Extracts
- Superparamagnetic iron oxide loaded chitosan coated bilosomes for magnetic nose to brain targeting of resveratrol.
- Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo
- Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
- Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents
- The Effect of Dietary Supplementation with Resveratrol on Growth Performance, Carcass and Meat Quality, Blood Lipid Levels and Ruminal Microbiota in Fattening Goats
- Glioprotective Effects of Resveratrol Against BMAA-Induced Astroglial Dysfunctions
- Micelle/Hydrogel Composite as a “Natural Self-Emulsifying Reversible Hybrid Hydrogel (N’SERH)” Enhances the Oral Bioavailability of Free (Unconjugated) Resveratrol
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