The central role of glutathione in the pathophysiology of human diseases
Explore this paper's citation graph
Summary
The current state of knowledge on the role of GSH is reviewed to underscore its relevance in translational research for future therapeutic treatment design and to modulate redox-sensitive components of signal transduction cascades.
- Type
- article
- Published
- 2007-01-01
- Cited by
- 541
- References
- 278
- OpenAlex
- https://openalex.org/W18158646
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35240599
Keywords
Political science, Constitution, Economic Justice, Administration (probate law), Administration of justice
References
- Free Radical Activity in Type 2 Diabetes
- Modulation of hepatic and intestinal glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats.
- Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
- Up-regulation of K(+) channels in diabetic rat ventricular myocytes by insulin and glutathione.
- Glutathione transferases.
- A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation.
- Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.
- Glutathione protects cells against arsenite-induced toxicity.
- Thermodynamic stoichiometry of Na+-coupled glutathione transport.
- Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal.
- Interaction between osmotic and oxidative stress in diabetic precataractous lens: studies with a sorbitol dehydrogenase inhibitor.
- Pentose Phosphate Pathway, Glutathione-Dependent Enzymes and Antioxidant Defense During Oxidative Stress in Diabetic Rodent Brain and Peripheral Organs: Effects of Stobadine and Vitamin E
- Beneficial and harmful effects of thiols.
- Caspase-3 activation is an early event and initiates apoptotic damage in a human leukemia cell line
- Free radicals and apoptosis: relationships with glutathione, thioredoxin, and the BCL family of proteins.
- Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils.
- Metabolism, not autoxidation, plays a role in α-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: Relevance for diabetes mellitus
- Reactive Oxygen as Modulator of TNF and Fas Receptor-Mediated Apoptosis In Vivo: Studies with Glutathione Peroxidase-Deficient Mice
- Antioxidant Role of Glutathione S-Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis
- Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
Cited by
- Antischistosomal and Hepatoprotective Activity of Morus alba Leaves Extract
- Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity
- Glutathione deficiency down-regulates hepatic lipogenesis in rats
- Erythrocyte glutathione concentration and production during hyperinsulinemia, hyperglycemia, and endotoxemia in healthy humans.
- Hormesis and public health: can glutathione depletion and mitochondrial dysfunction due to very low-dose chronic exposure to persistent organic pollutants be mitigated?
- Impact of metabolic perturbation on ovarian function
- Characterization of System xc -, a Cystine-Glutamate Amino Acid Transporter, as an Effector of Interleukin-1β-Mediated Injury and Neuroprotection
- Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats.
- Mechanisms of Neuronal Death Induced by Environmental Toxicants in Murine Cortical Culture
- Identification et mécanisme d'action de modulateurs sélectifs du transporteur ABCG2 responsable de la chimiorésistance de cellules cancéreuses
- CYTOCHROME P450 2E1 - RELEVANCE FOR CENTRAL DOPAMINE NEUROTRANSMISSION AND PARKINSON'S DISEASE
- Effect of N-(D-Ribopyranosyl)taurine Sodium Salt Supplementation on the Hepatic Antioxidant System in Rat Models of Diet-Induced Obesity and Taurine Deficiency.
- Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression
- Electrochemical determination of free and total glutathione in human saliva samples
- Human Waste - A Potential Resource: Converting Trash into Treasure by Embracing the 5 R’s Philosophy for Safe and Sustainable Waste Management
- Regulation of Platelet Activity in a Changing Redox Environment
- Research Advance on Reduced Glutathione
- Nitric oxide and reactive oxygen species in the nucleus revisited.
- Detection of Intracellular Glutathione Using ThiolTracker Violet Stain and Fluorescence Microscopy
- Endogenous antioxidants and radical scavengers.
Related papers
No related papers recorded.