Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands.
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Summary
The expression, regulation and function of different TLRs are reviewed, with an emphasis on TLR-4, and how TLR adaptor protein binding directs intracellular signaling resulting in activation or termination of an innate immune response is highlighted.
- Type
- article
- Published
- 2020-12-21
- Cited by
- 14
- References
- 145
- OpenAlex
- https://openalex.org/W3117279292
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:229353396
Keywords
Innate immune system, Pattern recognition receptor, Signal transducing adaptor protein, Receptor, Signal transduction
References
- A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
- A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
- Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs1
- Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
- The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
- Signal transduction via the B-cell antigen receptor: the role of protein tyrosine kinases and protein tyrosine phosphatases.
- The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
- SETD6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κB signaling
- Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
- Toll-like receptors and innate immunity
- MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR31
- The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
- Epithelioid cells from foreign‐body granuloma selectively express the calcium‐binding protein MRP‐14, a novel down‐regulatory molecule of macrophage activation
- IκB kinase complexes: gateways to NF-κB activation and transcription
- Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development
- Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip
- Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
- The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
- Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
- SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human.
Cited by
- The Yin and Yang of alarmin S100B in the protection of myocardium.
- What's New In Shock, August 2021?
- Fibronectin Functions as a Selective Agonist for Distinct Toll-like Receptors in Triple-Negative Breast Cancer
- Goose STING mediates IFN signaling activation against RNA viruses
- Metadichol® induced expression of the TLR family of receptors in PBMCs
- Lactobacillus delbrueckii Alleviate Oxidative Stress and Intestinal Injuries by Activating TLR2 and TLR4 Expressions in IPEC-J2 Cells
- Toll-like receptor signaling in teleosts
- Antiviral effects and mechanism of Ma-Xing-Shi-Gan-San on porcine reproductive and respiratory syndrome virus
- Experimental verification of Myriocin molecular bioactivity in revoking rheumatoid arthritis: New emphasis on S100A1 repression and PPAR-γ activation via non-canonical pathways in the flare-up of cytokines.
- Integration of proteomics and bioinformatics in traumatic brain injury biomarker discovery
- Modulation of Toll-like Receptors with Natural Compounds: A Therapeutic Avenue Against Inflammaging?
- Antiviral Effect and Mechanism of Ma-Xing-Shi-Gan-San Against Porcine Reproductive and Respiratory Syndrome Virus Via Network Pharmacology and Molecular Docking
- The Diagnostic Promise of Serum S100B Protein in Pregnancy‐Related Hypertension: A Narrative Review
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