Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway
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Summary
Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular Histone-enhanced collagen I in CCl4-induced liver fibrosis.
- Type
- article
- Published
- 2020-12-21
- Cited by
- 17
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W3114544921
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:229718997
Keywords
Hepatic stellate cell, Fibrosis, Histone, Liver injury, Cancer research
References
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- Histological grading and staging of chronic hepatitis.
- Nucleosomes in Serum as a Marker for Cell Death
- Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms
- Apoptotic Release of Histones from Nucleosomes*
- Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.
- Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
- Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture
- Toll-Like Receptor Signaling Pathways
- Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
- Endogenous Histones Function as Alarmins in Sterile Inflammatory Liver Injury through Toll-like Receptor 9
- Inhibitory effect of heparin on collagen fiber formation in hepatic cells in culture.
- Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Cited by
- Role of TLR4/MyD88 Signaling Pathway in the Occurrence and Development of Uremia-Induced Myocardial Hypertrophy and Possible Mechanism
- Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis
- MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
- Identification and characterization of proteins that form the inner core Ixodes scapularis tick attachment cement layer
- Liquid Liver Biopsy for Disease Diagnosis and Prognosis
- Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27
- Role of pattern recognition receptors in the development of MASLD and potential therapeutic applications.
- Nets in fibrosis: Bridging innate immunity and tissue remodeling.
- Emerging therapeutic strategies targeting extracellular histones for critical and inflammatory diseases: an updated narrative review
- Advances in the Preparation and Bioactivity of Polysaccharides From Medicinal Plants With Different Molecular Weights: A Review
- The Roles of Neutrophil Cells in the Pathogenesis of Fibrosis: Mechanisms for Disease Progression
- The Role of Extracellular Histones in Disease Progression: A Potential Therapeutic Target for Disease Modulation.
- Context-dependent contribution of peptidyl arginine deiminase 4 (PAD4) to neutrophil extracellular trap formation and liver injury in acute and chronic hepatotoxicant challenge
- Itaconate regulates PANoptosis in splenocytes to alleviate sepsis-induced multiple organ dysfunction syndrome.
- The Molecular Network of Neutrophil Extracellular Traps in Hepatocellular Carcinoma: Biogenesis, Function, and Therapeutic Implications
- Barrier breakdown: lung-brain crosstalk in systemic inflammation
- Emerging biomodels to understand the pathophysiology of sepsis and evaluate new therapeutic strategies targeting extracellular histones
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