Emerging therapeutic strategies targeting extracellular histones for critical and inflammatory diseases: an updated narrative review
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Summary
Advances in histone-targeting therapy strategies with heparin, anti-histone antibodies, histone-binding proteins or molecules, and histone-affinity hemoadsorption are summarized in pre-clinical studies to promote better management of patients with histone-related diseases.
- Type
- review
- Published
- 2024-08-14
- Cited by
- 23
- References
- 218
- Access
- Open access
- OpenAlex
- https://openalex.org/W4401592758
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:271877916
Keywords
Histone, Medicine, Organ dysfunction, Neutrophil extracellular traps, Immunology
References
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Cited by
- “The NET effect”: Neutrophil extracellular traps—a potential key component of the dysregulated host immune response in sepsis
- Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 2: implementation strategies
- Neutrophil Extracellular Traps in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Diagnostic and Clinical Significance—A Review of the Current Literature
- Kringle-Dependent Inhibition of Plasmin-Mediated Fibrinolysis by Native and Citrullinated Core Histones
- Deciphering conundrums on heparins and circulating histones: hype or hope?
- Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy
- The Role of Extracellular Histones in Disease Progression: A Potential Therapeutic Target for Disease Modulation.
- Beyond Killing: The Overlooked Contribution of Neutrophils to Tissue Repair
- Innate Immune Surveillance and Recognition of Epigenetic Marks
- Simultaneous Removal of Endotoxin and Circulating Histones by Heparin-Grafted Chitosan-Cellulose Composite Microspheres for Multitargeted Hemoperfusion in Septic Blood.
- Beyond the linker: Histone H1 as a dynamic epigenetic hub governing chromatin plasticity and disease pathogenesis.
- Nanobodies for NETosis Tracking and Visualization
- Global Research Trends in Sepsis-Associated Coagulopathy: A Web of Science-Based Bibliometric Analysis (2000–2024)
- Sepsis-induced coagulopathy: recent insights on the role and clinical application of neutrophil extracellular trap formation
- Innate Immune Surveillance and Recognition of Epigenetic Marks
- Interactions between neutrophil extracellular traps and macrophages: the key to inflammatory diseases
- Study on the pro-inflammatory injury of neutrophil extracellular traps in gouty nephropathy
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