Immunological Characteristics of Hyperprogressive Disease in Patients with Non-small Cell Lung Cancer Treated with Anti-PD-1/PD-L1 Abs
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Summary
When peripheral blood immune cells were examined, the pre-treatment frequency of CD39+ cells among CD8+ T cells was significantly higher in patients with HPD compared to those with NHPD, although it showed borderline significance to predict HPD.
- Type
- article
- Published
- 2020-12-01
- Cited by
- 8
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W3114521516
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:230802702
Keywords
Medicine, CD8, Immune system, Flow cytometry, Peripheral blood mononuclear cell
References
- Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
- Overcoming T cell exhaustion in infection and cancer
- CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
- Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
- Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1
- Hyper-progressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate
- Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
- T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
- CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells.
- Blockade of Tumor-Expressed PD-1 promotes lung cancer growth
- Cancer Immunotherapy Using Checkpoint Blockade
- Hyperprogressive Disease in Patients With Advanced Non–Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy
- Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
- The Ratio of Peripheral Regulatory T Cells to Lox-1+ Polymorphonuclear Myeloid-derived Suppressor Cells Predicts the Early Response to Anti-PD-1 Therapy in Patients with Non-Small Cell Lung Cancer.
- Hyperprogressive disease: recognizing a novel pattern to improve patient management
- The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- Hyperprogressive disease during PD-1/PD-L1 blockade in patients with non-small-cell lung cancer.
- PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
- Comprehensive Clinical and Genetic Characterization of Hyperprogression Based on Volumetry in Advanced Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitor.
Cited by
- 晚期非小细胞肺癌免疫治疗超进展的研究进展
- Establishment of a mechanism-based in vitro coculture assay for evaluating the efficacy of immune checkpoint inhibitors
- Early mortality factors in immune checkpoint inhibitor monotherapy for advanced or metastatic non-small cell lung cancer
- Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
- Incidence of immunotherapy‐related hyperprogressive disease (HPD) across HPD definitions and cancer types in observational studies: A systematic review and meta‐analysis
- Further knowledge and developments in resistance mechanisms to immune checkpoint inhibitors
- Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy
- 238 Meta-analysis on the incidence of hyperprogressive disease during immune checkpoint inhibitor therapy
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