Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
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Summary
The dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP 3(+) subpopulations.
- Type
- article
- Published
- 2009-06-19
- Cited by
- 2,312
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2007631222
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11436427
Keywords
Biology, Transcription factor, FOXP3, Cell biology, Transcription (linguistics)
References
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- Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
- The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
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- FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions.
- Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
- FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans
- An essential role for Scurfin in CD4+CD25+ T regulatory cells
- Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model.
- Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
- Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
- Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.
- Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level.
- Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.
- Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population
- Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
Cited by
- Understanding Recurrent Disease: A Dynamical Systems Approach
- Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants
- Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
- Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species
- IL-7 Abrogates Suppressive Activity of Human CD4+CD25+FOXP3+ Regulatory T Cells and Allows Expansion of Alloreactive and Autoreactive T Cells
- Analysis of Suppressor and Non-Suppressor FOXP3+ T Cells in HIV-1-Infected Patients
- Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 cell counts
- Regulatory T-cell immunotherapy for allogeneic hematopoietic stem-cell transplantation
- Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
- Increased Frequency of CD4 and CD8 Regulatory T Cells in Individuals under 15 Years with Multibacillary Leprosy
- HIV Infection Deregulates the Balance Between Regulatory T Cells and IL-2–Producing CD4 T Cells by Decreasing the Expression of the IL-2 Receptor in Treg
- The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions
- The multifaceted role of CD4+ T cells in the regulation of CD8+ T cell memory maturation
- Biology and clinical observations of regulatory T cells in cancer immunology.
- Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection
- Tolerancia inmunológica y trasplante renal
- CD4+CD25+ T Regulatory Cells in Transplantation Tolerance: 25 Years On
- Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice
- Tumour‐associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice
- Association of increased Treg and Th17 with pathogenesis of moyamoya disease
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