CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways.
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Summary
Evidence is provided for CaV2.2 VGCCs as novel targets for SUMOylation pathways after co-expression of SUMO-1 and Ubc9 caused an increase in whole-cell maximal conductance and a hyperpolarizing shift in the midpoint of activation (V1/2).
- Type
- article
- Published
- 2020-11-30
- Cited by
- 7
- References
- 46
- OpenAlex
- https://openalex.org/W3108409149
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:229385503
Keywords
SUMO protein, Cell biology, Voltage-dependent calcium channel, Excitatory postsynaptic potential, SUMO enzymes
References
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- The "megaprimer" method of site-directed mutagenesis.
- Neural Activity Selects Myosin IIB and VI with a Specific Time Window in Distinct Dynamin Isoform-Mediated Synaptic Vesicle Reuse Pathways
- SUMO1 enhances cAMP‐dependent exocytosis and glucagon secretion from pancreatic α‐cells
- Characterization of a Fission Yeast SUMO-1 Homologue, Pmt3p, Required for Multiple Nuclear Events, Including the Control of Telomere Length and Chromosome Segregation
- The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
- RIM1α SUMOylation Is Required for Fast Synaptic Vesicle Exocytosis
- Mechanisms, regulation and consequences of protein SUMOylation
- Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner
- A cholinergic model synapse to elucidate protein function at presynaptic terminals.
- An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels*
- SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting*
- β-Subunits Promote the Expression of CaV2.2 Channels by Reducing Their Proteasomal Degradation
- Differential ubiquitination and proteasome regulation of CaV2.2 N-type channel splice isoforms
- Molecular targets underlying SUMO‐mediated neuroprotection in brain ischemia
- Concepts in sumoylation: a decade on
- The Small Ubiquitin-like Modifier-1 (SUMO-1) Consensus Sequence Mediates Ubc9 Binding and Is Essential for SUMO-1 Modification*
- One SUMO is sufficient to silence the dimeric potassium channel K2P1
- Analysis of SUMO-1 modification of neuronal proteins containing consensus SUMOylation motifs
Cited by
- Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons
- Effects of short-term exposure to volatile pesticide dichlorvos on the olfactory systems in Spodoptera litura: Calcium homeostasis, synaptic plasticity and apoptosis.
- Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain
- Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation
- Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation
- SUMOylation and DeSUMOylation: Tug of War of Pain Signaling
- Downregulation of Hmox1 and Rpgrip1l Expression Linked to Risk-Taking Behavior, Reduced Depressive Symptoms, and Diminished Novelty Socialization in SUMO1 Knockout Mice
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