Sumo Modification of Ion Channels.
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Summary
These studies expand the list of known functions of sumoylation and reveal that, in addition to its more established role in the regulation of nuclear proteins, this modification plays important roles at the cytoplasmic face of membranes.
- Type
- review
- Published
- 2017-01-01
- Cited by
- 19
- References
- 50
- OpenAlex
- https://openalex.org/W19539656
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16277
Keywords
SUMO protein, Ion channel, Cell biology, Cytoplasm, Chemistry
References
- Regulation of ligand-gated ion channels by protein phosphorylation.
- Palmitylation, sulfation, and glycosylation of the alpha subunit of the sodium channel. Role of post-translational modifications in channel assembly.
- Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels
- Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction
- The ubiquitin‐like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer
- New antiarrhythmic agents for atrial fibrillation and atrial flutter
- Advances in antiarrhythmic drug treatment of atrial fibrillation: where do we stand now?
- In Vivo Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide IKur Blocker, (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide, in Rat and Nonhuman Primate
- Activity‐dependent endocytic sorting of kainate receptors to recycling or degradation pathways
- A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 Is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis*
- A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
- In Vivo Antiarrhythmic and Cardiac Electrophysiologic Effects of a Novel Diphenylphosphine Oxide IKur Blocker (2-Isopropyl-5-methylcyclohexyl) Diphenylphosphine Oxide
- Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3*
- Concepts in sumoylation: a decade on
- Differences between outward currents of human atrial and subepicardial ventricular myocytes.
- Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance.
- SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5
- Analysis of SUMO-1 modification of neuronal proteins containing consensus SUMOylation motifs
- Pias1 Interaction and Sumoylation of Metabotropic Glutamate Receptor 8*
- Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.
Cited by
- Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
- CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
- Different SUMO Paralogs Determine the Fate of WT and Mutant CFTRs: Biogenesis vs. Degradation
- The SUMO-specific protease family regulates cancer cell radiosensitivity.
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis
- Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation
- Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
- The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake
- SUMOylation of synaptic and synapse‐associated proteins: An update
- CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways.
- SUMOylation of the Kv4.2 Ternary Complex Increases Surface Expression and Current Amplitude by Reducing Internalization in HEK 293 Cells
- Sumoylation in Physiology, Pathology and Therapy
- SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons
- Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms
- Deciphering the role of cytoplasmic domain of Channelrhodopsin in modulating the interactome and SUMOylome of Chlamydomonas reinhardtii.
- Paralogue-Specific Roles of SUMO1 and SUMO2/3 in Protein Quality Control and Associated Diseases
- Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation
- Alternative splicing of the SUMO transcripts contributes to the regulation of the cellular SUMOylation system and produces messages coding for protein isoforms functionally distinct from the prototypical SUMO proteins
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