Effects of miR-146a-5p on chondrocyte interleukin-1β-induced inflammation and apoptosis involving thioredoxin interacting protein regulation
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Summary
It is suggested that miR-146a-5p inhibits cell proliferation and promotes apoptosis and the inflammatory response in OA cartilage injury by modulating TXNIP.
- Type
- article
- Published
- 2020-11-01
- Cited by
- 21
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W3102348010
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:226285860
Keywords
TXNIP, Apoptosis, Gene knockdown, Chondrocyte, microRNA
References
- Osteoarthritis: an update with relevance for clinical practice
- Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis
- The microRNA-29 family in cartilage homeostasis and osteoarthritis
- Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes
- The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
- Commentary on recent therapeutic guidelines for osteoarthritis.
- Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
- Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet
- Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes.
- Effects of diacerein at the molecular level in the osteoarthritis disease process
- Osteoarthritis: From Palliation to Prevention: AOA Critical Issues.
- Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
- How Do MicroRNAs Regulate Gene Expression?
- Hsa‐miR‐146a‐5p modulates androgen‐independent prostate cancer cells apoptosis by targeting ROCK1
- Signature of circulating microRNAs in osteoarthritis.
- MiR-502-5p inhibits IL-1β-induced chondrocyte injury by targeting TRAF2.
- Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy
- MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis
- Down-regulation of microRNA-216b inhibits IL-1β-induced chondrocyte injury by up-regulation of Smad3
- Models to define the stages of articular cartilage degradation in osteoarthritis development
Cited by
- Establishing SW1353 Chondrocytes as a Cellular Model of Chondrolysis
- Positive feedback loop of lncRNA FAM201A/miR-146a-5p/POU2F1 regulates IL-1β-induced chondrocyte injury in vitro
- Crosstalk Among circRNA/lncRNA, miRNA, and mRNA in Osteoarthritis
- Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response
- Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
- microRNA-301b-3p from mesenchymal stem cells-derived extracellular vesicles inhibits TXNIP to promote multidrug resistance of gastric cancer cells
- Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders?
- Loganin attenuates interleukin-1β-induced chondrocyte inflammation, cartilage degeneration, and rat synovial inflammation by regulating TLR4/MyD88/NF-κB
- MicroRNA as Possible Mediators of the Synergistic Effect of Celecoxib and Glucosamine Sulfate in Human Osteoarthritic Chondrocyte Exposed to IL-1β
- MicroRNAs as Prognostic Biomarkers and Therapeutic Targets in Chondrosarcoma
- LncRNA AC005165.1 Alleviates IL-1β-Induced Osteoarthritis via miR-199a-3p/TXNIP Axis
- Dysregulation of miR‐146a is associated with exacerbated inflammation, oxidative and endoplasmic reticulum stress in the progression of diabetic foot ulcer
- ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation
- NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway
- Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma
- The Pivotal Role of Thioredoxin-Interacting Protein in Joint Degenerative Diseases
- Targeting Txnip-mediated metabolic reprogramming has therapeutic potential for osteoarthritis
- The Role of miR-146a/IRAK1/JNK1 Pathway in Mediating the Effects of Yiqi Congming Decoction on Dry Eye: A Mechanistic Study in Rat Models.
- MicroRNA-146a-3p as an alternative to anti-IL-6 monoclonal antibody therapy: Intra-articular liposome delivery for osteoarthritis treatment
- Epigenetics and Herbs: Potential Therapeutic Strategies for Osteoarthritis of the Knee
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