NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway
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Summary
The data indicated that NUMB regulated PTOA progression through the BTRC/NF-κB pathway, which may be a viable therapeutic target in PTOA.
- Type
- article
- Published
- 2024-08-23
- Cited by
- 1
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W4401803578
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:271929249
Keywords
NUMB, Viability assay, Chondrocyte, Cartilage, Inflammation
References
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- A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4
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- Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
- Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals
- Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
- Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.
- Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
- MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
- Control of daughter cell fates during asymmetric division: interaction of Numb and Notch.
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
- Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.
- A novel NF-κB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis
- Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation
- Total knee arthroplasty for treatment of post-traumatic arthritis: Systematic review
- DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes
- High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients
- Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis
- TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling
- Thickness of the bone-cartilage unit in relation to osteoarthritis severity in the human hip joint
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