Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice
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Summary
Overall, cilium KO mice demonstrated severely delayed and incomplete fracture healing, and the findings suggest Prx1-expressing cell primary cilia are necessary to tune Hh signaling for proper fracture repair.
- Type
- article
- Published
- 2020-11-11
- Cited by
- 14
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W3101970418
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:226961398
Keywords
Cell biology, Bone healing, Wnt signaling pathway, Downregulation and upregulation, Chondrogenesis
References
- Osteogenic Differentiation of Periosteal Cells During Fracture Healing
- Overview of Fracture Healing and Its Assessment
- Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair.
- The primary cilium functions as a mechanical and calcium signaling nexus
- Analysis of αSMA-Labeled Progenitor Cell Commitment Identifies Notch Signaling as an Important Pathway in Fracture Healing
- Platelet-Derived Growth Factor Receptor Alpha as a Marker of Mesenchymal Stem Cells in Development and Stem Cell Biology
- Expression of CD105 and CD34 receptors controls BMP‐induced in vitro mineralization of mouse adipose‐derived stem cells but does not predict their in vivo bone‐forming potential
- Coordination of TGFβ/BMP signaling is associated with the primary cilium
- Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells
- Intraflagellar transport is essential for endochondral bone formation
- Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.
- Wnt Signaling During Fracture Repair
- Modulation of Wnt Signaling Influences Fracture Repair
- Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering
- A ROLE FOR THE PRIMARY CILIUM IN PARACRINE SIGNALING BETWEEN MECHANICALLY STIMULATED OSTEOCYTES AND MESENCHYMAL STEM CELLS
- Current Insights on the Regenerative Potential of the Periosteum: Molecular, Cellular & Endogenous Engineering Approaches
- The Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing
- BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
- Meteorological Influences on the Incidence of Aneurysmal Subarachnoid Hemorrhage – A Single Center Study of 511 Patients
- Identification of a prx1 limb enhancer
Cited by
- The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation
- Cilia kinases in skeletal development and homeostasis
- Role of Primary Cilia in Bone and Cartilage
- Tracing PRX1+ cells during molar formation and periodontal ligament reconstruction
- Periosteal Skeletal Stem and Progenitor Cells in Bone Regeneration
- Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing
- Primary Cilia: The New Face of Craniofacial Research
- Primary cilia support cartilage regeneration after injury
- PRRX1+MSCs Enhance Mandibular Regeneration during Distraction Osteogenesis
- A periosteum-derived cell line to study the role of BMP/TGFβ signaling in periosteal cell behavior and function
- Recent advances in primary cilia in bone metabolism
- LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels
- Mechanosensory role and clinical potential of primary cilia in bone and tooth
- Osteoporosis: Emerging targets on the classical signaling pathways of bone formation
- Primary cilium of Prrx1+ cells mediate bone-tendon interface development by regulating cell biology
- An ex vivo appositional growth model to study periosteal activity and associated BMP signaling
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