Expression of CD105 and CD34 receptors controls BMP‐induced in vitro mineralization of mouse adipose‐derived stem cells but does not predict their in vivo bone‐forming potential
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Summary
It is found that in vitro BMP‐responsiveness is not a good indicator to predict in vivo bone forming potential of ADSCs, therefore greater precautions should be executed during selection of competent ADSCs for bone repair.
- Type
- article
- Published
- 2015-05-01
- Cited by
- 6
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1535695101
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21087638
Keywords
CD34, Stem cell, Bone morphogenetic protein 2, Endoglin, Bone morphogenetic protein
References
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- Two cell lines from bone marrow that differ in terms of collagen synthesis, osteogenic characteristics, and matrix mineralization.
- Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double‐blind study of 102 postmenopausal women with distal radial fractures
- The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces.
- Is CD34 Truly a Negative Marker for Mesenchymal Stem Cells?
- Osteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro
- Directed Differentiation of Human Induced Pluripotent Stem Cells Toward Bone and Cartilage: In Vitro Versus In Vivo Assays
- Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.
- Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions.
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.
- Levels of Expression for BMP-7 and Several BMP Antagonists May Play an Integral Role in a Fracture Nonunion: A Pilot Study
- Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
- BMP-Non-Responsive Sca1+CD73+CD44+ Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation
- Global gene profiling reveals a downregulation of BMP gene expression in experimental atrophic nonunions compared to standard healing fractures
- Intracutaneously injected human adipose tissue-derived stem cells in a mouse model stay at the site of injection.
- Binding of L-selectin to the vascular sialomucin CD34.
- CD90 (Thy-1)-Positive Selection Enhances Osteogenic Capacity of Human Adipose-Derived Stromal Cells
- Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells
- Perivascular Stem Cells: A Prospectively Purified Mesenchymal Stem Cell Population for Bone Tissue Engineering
Cited by
- Migration ability and Toll-like receptor expression of human mesenchymal stem cells improves significantly after three-dimensional culture.
- Cyclic uniaxial compression of human stem cells seeded on a bone biomimetic nanocomposite decreases anti-osteogenic commitment evoked by shear stress.
- Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice
- Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection
- Stimulation of bone regeneration using bone morphogenetic proteins: modern concepts
- Adipose Stem Cell-Derived Apoptotic Vesicles Attenuate Hypertrophic Scarring by Targeting the CDC20/WNT Signaling Pathway
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