Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.
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Summary
This review will present the newest mechanistic and therapeutic advances in the Notch field and discuss the promises and challenges of this constantly evolving field.
- Type
- review
- Published
- 2020-10-09
- Cited by
- 25
- References
- 167
- OpenAlex
- https://openalex.org/W3092249786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:222237622
Keywords
Notch signaling pathway, Cancer, Immunotherapy, Biology, Computational biology
References
- Role of Deltex-1 as a Transcriptional Regulator Downstream of the Notch Receptor*
- A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions
- Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
- Stabilization of Notch1 by the Hsp90 Chaperone is Crucial for T-Cell Leukemogenesis
- Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses
- Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation
- Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis
- Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model.
- The Many Substrates of Presenilin/γ-Secretase
- Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors
- Comprehensive genomic profiles of small cell lung cancer
- The Theory of the Gene
- Multivalent forms of the Notch ligand DLL-1 enhance antitumor T cell immunity in lung cancer and improve efficacy of EGFR targeted therapy
- PI3K/AKT signaling inhibits NOTCH1 lysosome‐mediated degradation
- Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway.
- The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.
- Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.
- Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
- Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.
- NOTCH and PI3K-AKT pathways intertwined.
Cited by
- Notch Signaling in Prevention And Therapy: Fighting Cancer with a Two-Sided Sword.
- ZFPM2‐AS1 facilitates cell proliferation and migration in cutaneous malignant melanoma through modulating miR‐650/NOTCH1 signaling
- Delta C2 Domain β1-2 loop contributes to robust Notch signalling
- High Expressions of Notch and Survivin in Elderly Patients with Glioma Contribute to an Unfavorable Prognosis
- Myelin and lymphocyte protein 2 regulates cell proliferation and metastasis through the Notch pathway in prostate adenocarcinoma
- NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target.
- The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling
- [Inhibition of the Notch1/Jagged1 pathway promotes homing of bone mesenchymal stem cells to improve asthma in rats].
- Intrinsically disordered proteins play diverse roles in cell signaling
- In vivo Evaluation of Non-viral NICD Plasmid-Loaded PLGA Nanoparticles in Developing Zebrafish to Improve Cardiac Functions
- Modulation of Notch Signaling Pathway by Bioactive Dietary Agents
- Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses
- Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance.
- The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients
- Identification of necroptosis-related long non-coding RNAs prognostic signature and the crucial lncRNA in bladder cancer
- Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanisms
- Advances in research on potential inhibitors of multiple myeloma.
- Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review
- Bulk integrated single-cell-spatial transcriptomics reveals the impact of preoperative chemotherapy on cancer-associated fibroblasts and tumor cells in colorectal cancer, and construction of related predictive models using machine learning.
- Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p
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