Comprehensive genomic profiles of small cell lung cancer
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Summary
This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
- Type
- article
- Published
- 2015-07-13
- Cited by
- 2,075
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W1903523058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205244815
Keywords
Biology, Cancer research, Somatic cell, Gene, Chromothripsis
References
- Variable mutations of the RB gene in small-cell lung carcinoma.
- Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer.
- A Genomics-Based Classification of Human Lung Tumors
- On the elucidation of a tumour suppressor role of 3p in lung cancer
- Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer
- Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.
- Two genetic hits (more or less) to cancer
- A Continuum Model for Tumour Suppression
- Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.
- Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors
- Possible roles of DLK1 in the Notch pathway during development and disease.
- Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.
- Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond
- PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
- p53: a frequent target for genetic abnormalities in lung cancer.
- Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
- Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing
- Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer.
- The P16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung.
- LOSS OF P130 ACCELERATES TUMOR DEVELOPMENT IN A MOUSE MODEL FOR HUMAN SMALL CELL LUNG CARCINOMA
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- High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer
- EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?
- Notch Signaling in Development, Tissue Homeostasis, and Disease.
- Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies
- Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
- Transcriptional deregulation underlying the pathogenesis of small cell lung cancer.
- Transformation to small cell lung cancer after first-line afatinib treatment
- Whole Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma in-situ
- Talazoparib is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts
- Cell-Free DNA and Neuromediators in Detecting Aggressive Variant Prostate Cancer
- Molecular and Morphological Profiling of Lung Cancer: A Foundation for “Next-Generation” Pathologists and Oncologists
- A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
- Origins, genetic landscape, and emerging therapies of small cell lung cancer
- Prognosis, Prediction and Risk Assessment in the Prevention and Treatment of Non-Small Cell Lung Cancer
- Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases.
- Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
- Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors
- Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample
- p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem-like Features via miR-885-5p Control.
- What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?
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